Characteristics of Critically Ill Patients with COVID-19 Compared to Patients with Influenza—A Single Center Experience
Abstract
:1. Introduction
2. Materials and Methods
2.1. Hospital Setting
2.2. Patient Population
2.2.1. COVID-19 Cohort
2.2.2. Influenza Cohort
2.3. Treatment Protocols
2.3.1. General Treatment
2.3.2. Specific Treatment
2.4. Statistic
3. Results
3.1. Baseline Characteristics of Patient Groups
3.2. Clinical Endpoints
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Influenza (n = 64) | COVID-19 (n = 64) | |
---|---|---|
2016/2017 flu season | 27 | 0 |
2017/2018 flu season | 11 | 0 |
2018/2019 flu season | 17 | 0 |
2019/2020 flu season | 9 | 0 |
January 2020–July 2020 | n/a | 64 |
Influenza A (non H1N1) | 22 | |
Influenza A (H1N1) | 36 | |
Influenza B | 6 | |
SARS-CoV-2 | 64 |
Standardized Protocol for ARDS |
---|
Diagnostics on Admission |
|
|
|
|
Therapy |
|
|
|
|
Specific Treatment | n |
---|---|
Influenza—patients | |
| 60 |
COVID-19—patients | |
| 12 |
| 26 |
| 8 |
| 2 |
Influenza (n = 64) | COVID-19 (n = 64) | Std Diff # | p-Value | |
---|---|---|---|---|
Age [years] | 54.1 (49.8; 58.4) | 60.1 (56.9; 63.3) | 0.39 | 0.0211 § |
Sex [male] | 41 (64%) | 54 (84%) | 0.40 | 0.0292 $ |
BMI [kg m−2] | 30.2 (27.9; 32.5) | 28.8 (25.2; 32.4) | 0.18 | 0.5669 § |
Charlson Comorbidity Index | 2.53 (1.93; 3.13) | 2.48 (2.00; 2.97) | 0.02 | 0.9847 § |
Active Smoker | 16 (25%) | 4 (6.3%) | 0.53 | 0.0037 $ |
Transfer from other hospital | 39 (60.9%) | 43 (67.2%) | 0.12 | 0.4651 $ |
SAPS II on admission | 30.92 (26.56; 35.27) | 36.90 (33.89; 39.91) | 0.40 | 0.0261 § |
Influenza (n = 64) | COVID-19 (n = 64) | p-Value | |
---|---|---|---|
Mortality | 19 (29.7%) | 22 (34.3%) | 0.568 |
Any ECMO | 29 (45.3%) | 18 (28.1%) | 0.044 |
Mortality with ECMO | 11/29 (37.9%) | 12/18 (66.7%) | 0.055 |
Invasive ventilation | 56 (87.5%) | 50 (78.1%) | 0.160 |
Time in ICU [days] | 23.1 (15.9; 30.3) | 15.5 (12.3; 18.7) | 0.0549 |
Any dialysis (CVVHD) in ICU | 32 (50.0%) | 24 (37.5%) | 0.131 |
Any bacteremia | 46 (71.9%) | 33 (51.6%) | 0.023 |
Any invasive aspergillosis | 12 (18.8%) | 5 (7.8%) | 0.063 |
TISS points per day | 15.50 (12.77; 18.21) | 17.14 (13.77; 20.51) | 0.448 |
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Herbstreit, F.; Overbeck, M.; Berger, M.M.; Skarabis, A.; Brenner, T.; Schmidt, K. Characteristics of Critically Ill Patients with COVID-19 Compared to Patients with Influenza—A Single Center Experience. J. Clin. Med. 2021, 10, 2056. https://doi.org/10.3390/jcm10102056
Herbstreit F, Overbeck M, Berger MM, Skarabis A, Brenner T, Schmidt K. Characteristics of Critically Ill Patients with COVID-19 Compared to Patients with Influenza—A Single Center Experience. Journal of Clinical Medicine. 2021; 10(10):2056. https://doi.org/10.3390/jcm10102056
Chicago/Turabian StyleHerbstreit, Frank, Marvin Overbeck, Marc Moritz Berger, Annabell Skarabis, Thorsten Brenner, and Karsten Schmidt. 2021. "Characteristics of Critically Ill Patients with COVID-19 Compared to Patients with Influenza—A Single Center Experience" Journal of Clinical Medicine 10, no. 10: 2056. https://doi.org/10.3390/jcm10102056