Introduction

Older adults and those with underlying chronic medical disorders tend to be more susceptible to severe SARS-CoV-2 (COVID-19) [1, 2]. The population residing in long-term-care facilities (LTCFs) generally includes those who are both old and suffering from multiple comorbidities. A recent investigation conducted after the identification of a confirmed case of COVID-19 in a skilled nursing facility demonstrated the magnitude of the problem [3]. In this study, most of the residents with COVID-19 had respiratory illness at the moment of the diagnosis and the fatality rate was 33.7%. In another study conducted in younger residents of a skilled nursing facility, more than half of COVID-19 residents were judged asymptomatic before testing [4]. It is possible that older residents in LTCFs have specific initial atypical COVID-19 symptoms that need to be recognized rapidly.

Three residents living in a LTCF were admitted for severe non-respiratory symptoms. Case 1: March 3, 2020: diarrhea with dehydration and a severe health status impairment. Case 2: March 5, 2020: fall with a wrist fracture in a woman without significant balance disturbance. Case 3: March 6, 2020: delirium, hypothermia, and hypotension in a woman with previous moderate cognitive impairment. The three residents all developed respiratory symptoms (cough with fever and dyspnea) 7–10 days after their admission to hospital and nasopharyngeal swab test confirmed COVID-19 diagnosis. All three patients died 5–7 days after diagnosis. As soon as the diagnosis was made in the first resident, infection prevention and control (ICP) measures were immediately adopted in the LTCF.

The study attempted to assess the prevalence of COVID-19 infection in residents and staff members of the LTCF 7 days after the COVID-19 diagnosis of the first resident. The longitudinal symptoms of the residents were also assessed for 4 weeks.

Methods

Following local guidance, SARS-CoV-2 real-time reverse-transcriptase polymerase chain reaction (rRT-PCR) was used on nasopharyngeal swab tests in all 79 residents and 40 health workers and on the stools of five of the residents with diarrhea. This was an observational study approved by the Montpellier University Hospital Institutional Review Board (IRB-MTP_2020_06_202000534). Symptoms in the 14 days before positive testing and until March 30 were recorded in all residents.

Results

Among the 79 residents, 38 (48.1%) were positive for SARS-CoV-2 on March 18–20, 2020. Respiratory symptoms were preceded by diarrhea in 10 (26.3%) cases, a fall in 7 (18.4%), and hypothermia in 13 (34.2%). Respiratory symptoms appeared after those symptoms or as the first sign in 24 residents (63.2%), including a dry cough in 14 (36.8%) and hypoxemia in 21 (55.2%). At any time of the disease, fever was observed in 25 residents (65.3%), most often alternating with hypothermia in 13 residents (34.2%). Three residents had no symptoms at the time of testing (7.9%), but they developed fever and cough 3–10 days later. Besides the first three deaths in the hospitalized residents, nine other COVID-19-positive residents died during the follow-up period, always less than 10 days after initial testing. This represents a total fatality rate of 31.6% (12/38) in the residents tested positive for SARS-CoV-2. The residents who died had severe hypoxemia in 12 cases (100%), hectic fever in 10 (83.3%), and diarrhea in 9 (75.0%). In all 12 cases, maximum oxygen supply was not sufficient to restore normal blood oxygen saturation. All of these residents benefited from optimal end-of-life care, three in hospital and six in the LTCF.

Among the 41 residents tested negative for SARS-CoV-2, 22 (53.6%) had new symptoms in the 14 days before testing, including cough in 9 cases (21.9%), diarrhea in 3 (7.3%), fever in 2 (4.8%), hypothermia in 2 (4.8%), and dyspnea with transient hypoxemia in 4 (9.8%). No deaths were observed in this group (Table 1).

Table 1 Demographic and clinical characteristics
Full size table

In the five residents with diarrhea (two tested positive and three tested negative for SARS-CoV-2), all rectal swab tests by rRT-PCR were negative for SARS-CoV-2.

On March 19, 2020, 11 of the 40 staff members (27.5%) were tested positive for SARS-CoV-2. All of them were asymptomatic or had minor complaints, such as asthenia, in the 14 days before testing. On March 30, 2020, the progression of health status of all staff members tested positive for SARS-CoV-2 was favorable.

Discussion

The present case investigation provides novel insight into COVID-19 infection in old-age adults in LTCFs and extends the papers of McMichael et al. [3] and Arons et al. [4].

There were around 50% of COVID-19 infected residents and 27.5% of health care workers. This confirms that a few days after a first case of confirmed COVID-19 in a LTCF, the number of other residents and staff members linked to the first case can be very high [3].

The rapid dissemination of COVID-19 may, at least in part, be explained by the delay in the diagnosis in the first residents and, therefore, in the implementation of appropriate infection control practices (ICPs). The first possible reason for this delay may be related to asymptomatic forms of COVID-19 at the time of testing, such as in younger people [5], those patients representing 7.3% of residents tested positive for SARS-CoV-2 of our sample vs 56% in another study conducted by Arons in a skilled nursing facility [4]. All of these cases developed typical COVID-19 symptoms after testing in the present study which is in line with previous studies conducted in younger patients [4,5,6]. The second possible reason of the diagnosis delay may be related to atypical symptoms preceding the respiratory symptoms and fever, including diarrhea, hypothermia, or delirium. Another interesting feature is the relatively common fall rate as the first symptom. Since COVID-19 induces severe fatigue, it can be expected that falls can be common in residents with little or no risk of fall. This symptom needs to be considered as a possible prodromal symptom of COVID-19 during the epidemic in LTCF residents. Diarrhea prevalence has been shown to increase in the later stage of the COVID-19 disease and is often associated with COVID-19 infectious stools [7]. The present study suggests that diarrhea can be a prodromal sign of COVID-19, with stools that were not infectious in five of our patients with diarrhea.

The second factor that may explain, at least partly, the rapid and large COVID-19 outbreak in this LTCF is the high prevalence of staff members positive for SARS-CoV-2. The present data strongly support those of McMichel et al. [3], underlying the involuntary role of the health workers and visitors in the COVID-19 spread within this facility. They led us to take the decision to prohibit visits in the LCTF and to systematically screen for SARS-CoV-2 all staff members and residents (even asymptomatic) as soon as a case of COVID-19 was confirmed in the first resident.

In addition to appropriate ICP measures, the strategies of systematic testing residents with typical and atypical COVID-19 symptoms to diagnose early the first case, and then, of early testing for SARS-CoV-2 all residents, visitors, and staff members, even asymptomatic, may be useful in controlling COVID-19 outbreaks in LTCFs, and may contribute to decreasing the case fatality ratio of the disease.

In conclusion, the present study shows that the rapid dissemination of a COVID-19 infection in a LTCF may be due to a delay in the diagnosis of the first case, whose presentation could be atypical. An early recognition of atypical symptoms compatible with COVID-19 may help diagnose the first case earlier, allow early diagnosis of COVID-19 in staff, visitors, and other residents, and implement earlier targeted ICPs in the LTCF.