Clinical and laboratory profile of patients with COVID-19 admitted to hospital in Moscow between May and July 2020

Authors / Institutions

Lyudmila V. Kolobukhina / N.F.Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russian Federation

Olga A. Burgasova / Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation

M.L.Abramovich / Central Research Institute of Epidemiology of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation

Vladimir A. Gushchin / N.F.Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russian Federation / M.V.Lomonosov Moscow State University, Moscow, Russian Federation

Elena I. Burtseva / N.F.Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russian Federation

Irina S. Kruzhkova / N.F.Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russian Federation

Irina N. Khlopova / N.F.Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russian Federation

Liliya N. Merkulova / N.F.Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russian Federation

Kirill G. Krasnoslobodtsev / N.F.Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russian Federation

Nadezhda A. Kuznetsova / N.F.Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russian Federation

Elena V. Shidlovskaya / N.F.Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russian Federation

Darya A. Dvorkina / N.F.Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russian Federation

Vera B. Tetova / Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation

Valeriya V. Bakalina / Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation

Mikhail A. Odnoralov / Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation

Lyubov V. Generalova / Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation

Alina R. Khayrullina / L.Pasteur Research Institute of Epidemiology and Microbiology, Saint-Petersburg, Russian Federation

Natalya A. Antipyat / Clinical Hospital Infectious Diseases No 1, Moscow Healthcare Department, Moscow, Russian Federation

Aleksandr V. Shagaev / Clinical Hospital Infectious Diseases No 1, Moscow Healthcare Department, Moscow, Russian Federation

Olga E. Ambrosi / Clinical Hospital Infectious Diseases No 1, Moscow Healthcare Department, Moscow, Russian Federation

Elena I. Kelli / Clinical Hospital Infectious Diseases No 1, Moscow Healthcare Department, Moscow, Russian Federation

Elena E. Ushakova / Clinical Hospital Infectious Diseases No 1, Moscow Healthcare Department, Moscow, Russian Federation

Svetlana V. Smetanina / Clinical Hospital Infectious Diseases No 1, Moscow Healthcare Department, Moscow, Russian Federation

Objective. Data of the clinical picture forms of the disease, management and diagnostic capabilities of patients with COVID-19 continue to be studied. Our study presents results from the analysis of clinical and laboratory parameters of patients with COVID-19 in the period May-June 2020, who were treated in an infectious diseases hospital in Moscow.
Patients and methods. The analytical cohort included 444, 198 men, 246 women aged 18 to 95 years, who were identified with SARS-CoV-2 RNA. The severity of the disease was determined in accordance with the temporary clinical recommendations (version 6 effective April 28, 2020), NEWS.
Results. The study of the clinical picture showed the variability of the spectrum of clinical manifestations of COVID-19. The most common symptoms were fever, weakness, myalgia, dry cough, shortness of breath, diarrhea. The severity of the infection was not associated with the patient's gender, but was significantly correlated with age and the presence of comorbid status, which included chronic lung diseases, obesity, diabetes mellitus, and cardiovascular diseases. Observations of patients with severe and extremely severe course revealed characteristic laboratory markers of severity. The main method of etiological diagnosis was the RT-PCR method for detecting SARS-CoV-2 RNA in the nasopharyngeal secret. To verify COVID-19, we used an additional PCR method, fecal testing for the detection of SARS-CoV-2 RNA.
Key words: COVID-19, clinical features, risk factors, SARS-CoV-2 RNA, biological substrates
For citation: Kolobukhina L.V., Burgasova O.A., Kraeva L.A., Gushchin V.A., Burtseva E.I., Kruzhkova I.S., Khlopova I.N., Merkulova L.N., Krasnoslobodtsev
K.G., Kuznetsova N.A., Shidlovskaya E.V., Dvorkina D.A., Tetova V.B., Bakalin V.V., Odnoralov M.A., Generalova L.V., Khayrullina A.R., Antipyat N.A., Shagaev A.V., Ambrosi O.E., Kelli E.I., Ushakova E.E., Smetanina S.V. Clinical and laboratory profile of patients with COVID-19 admitted to hospital in Moscow between May and July 2020. Infekc. bolezni (Infectious diseases). 2021; 19(2): 5–15. (In Russian). DOI: 10.20953/1729-9225-2021-2-5-15