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47 Results       Page 1

 [1] 
American Chemical Society: Journal of Medicinal Chemistry
  original article Date Title Authors   All Authors
1 [GO] 2022―Nov―10 Two Binding Sites of SARS-CoV-2 Macrodomain 3 Probed by Oxaprozin and Meclomen Jiao Li, Fumei Zhong, Mingwei Li, Yaqian Liu, Lei Wang, Mingqing Liu, et al. (+8)
2 [GO] 2022―Oct―14 Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease Yuya Hirose, Naoya Shindo, Makiko Mori, Satsuki Onitsuka, Hikaru Isogai, Rui Hamada, et al. (+15)
3 [GO] 2022―Sep―30 Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease Mark S. Cooper, Linlin Zhang, Mohamed Ibrahim, Kaixuan Zhang, Xinyuanyuan Sun, Judith Röske, et al. (+12)
4 [GO] 2022―Sep―28 Targeting SARS-CoV-2 Main Protease for Treatment of COVID-19: Covalent Inhibitors Structure-Activity Relationship Insights and Evolution Perspectives Gabriele La Monica, Alessia Bono, Antonino Lauria, Annamaria Martorana
5 [GO] 2022―Sep―15 Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity Shenghua Gao, Katharina Sylvester, Letian Song, Tobias Claff, Lanlan Jing, Molly Woodson, et al. (+15)
6 [GO] 2022―Jun―22 Evolutionary and Structural Insights about Potential SARS-CoV-2 Evasion of Nirmatrelvir Kai S. Yang, Sunshine Z. Leeuwon, Shiqing Xu, Wenshe Ray Liu
7 [GO] 2022―Jun―16 Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination Thanigaimalai Pillaiyar, Philipp Flury, Nadine Krüger, Haixia Su, Laura Schäkel, Elany Barbosa Da Silva, et al. (+15)
8 [GO] 2022―May―31 Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-like Protease Chamandi S. Dampalla, Athri D. Rathnayake, Anushka C. Galasiti Kankanamalage, Yunjeong Kim, Krishani Dinali Perera, Harry Nhat Nguyen, et al. (+10)
9 [GO] 2022―May―27 Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease Haozhou Tan, Yanmei Hu, Prakash Jadhav, Bin Tan, Jun Wang
10 [GO] 2022―May―12 Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine Tika R. Malla, Lennart Brewitz, Dorian-Gabriel Muntean, Hiba Aslam, C. David Owen, Eidarus Salah, et al. (+6)
11 [GO] 2022―May―04 S-217622, a 3CL Protease Inhibitor and Clinical Candidate for SARS-CoV-2 Joel D. A. Tyndall
12 [GO] 2022―Apr―19 Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues Rostom Ahmed-Belkacem, Marcel Hausdorff, Adrien Delpal, Priscila Sutto-Ortiz, Agathe M. G. Colmant, Franck Touret, et al. (+7)
13 [GO] 2022―Mar―30 Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19 Yuto Unoh, Shota Uehara, Kenji Nakahara, Haruaki Nobori, Yukiko Yamatsu, Shiho Yamamoto, et al. (+19)
14 [GO] 2022―Feb―09 Advances Toward COVID-19 Therapies Special Issue Nouri Neamati
15 [GO] 2022―Feb―02 MPLA-Adjuvanted Liposomes Encapsulating S-Trimer or RBD or S1, but Not S-ECD, Elicit Robust Neutralization Against SARS-CoV-2 and Variants of Concern Jian Wang, Xu-Guang Yin, Yu Wen, Jie Lu, Ru-Yan Zhang, Shi-Hao Zhou, et al. (+3)
16 [GO] 2022―Jan―24 Self-Adjuvanting Lipoprotein Conjugate αGalCer-RBD Induces Potent Immunity against SARS-CoV-2 and its Variants of Concern Jian Wang, Yu Wen, Shi-Hao Zhou, Hai-Wei Zhang, Xiao-Qian Peng, Ru-Yan Zhang, et al. (+5)
17 [GO] 2022―Jan―04 Design and Evaluation of a Novel Peptide-Drug Conjugate Covalently Targeting SARS-CoV-2 Papain-like Protease Na Liu, Yichi Zhang, Yingshou Lei, Rui Wang, Meimiao Zhan, Jianbo Liu, et al. (+5)
18 [GO] 2021―Dec―05 Structure-Guided Design of Potent Inhibitors of SARS-CoV-2 3CL Protease: Structural, Biochemical, and Cell-Based Studies Chamandi S. Dampalla, Athri D. Rathnayake, Krishani Dinali Perera, Abdul-Rahman M. Jesri, Harry Nhat Nguyen, Matthew J. Miller, et al. (+9)
19 [GO] 2021―Nov―24 Stapled Peptides Targeting SARS-CoV-2 Spike Protein HR1 Inhibit the Fusion of Virus to Its Cell Receptor Mengjun Zheng, Wei Cong, Haoran Peng, Jie Qing, Huaxing Shen, Yaxin Tang, et al. (+6)
20 [GO] 2021―Nov―23 Colloidal Aggregators in Biochemical SARS-CoV-2 Repurposing Screens Henry R. O’Donnell, Tia A. Tummino, Conner Bardine, Charles S. Craik, Brian K. Shoichet
21 [GO] 2021―Nov―20 Perspectives on SARS-CoV-2 Main Protease Inhibitors Kaifu Gao, Rui Wang, Jiahui Chen, Jetze J. Tepe, Faqing Huang, Guo-Wei Wei
22 [GO] 2021―Oct―27 Structural, Electronic, and Electrostatic Determinants for Inhibitor Binding to Subsites S1 and S2 in SARS-CoV-2 Main Protease Daniel W. Kneller, Hui Li, Stephanie Galanie, Gwyndalyn Phillips, Audrey Labbé, Kevin L. Weiss, et al. (+11)
23 [GO] 2021―Oct―21 Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity Zhengnan Shen, Kiira Ratia, Laura Cooper, Deyu Kong, Hyun Lee, Youngjin Kwon, et al. (+7)
24 [GO] 2021―Oct―09 Computational Design of Potent D-Peptide Inhibitors of SARS-CoV-2 Pedro A. Valiente, Han Wen, Satra Nim, JinAh Lee, Hyeon Ju Kim, Jinhee Kim, et al. (+6)
25 [GO] 2021―Sep―27 Discovery and Mechanism of SARS-CoV-2 Main Protease Inhibitors Sarah Huff, Indrasena Reddy Kummetha, Shashi Kant Tiwari, Matthew B. Huante, Alex E. Clark, Shaobo Wang, et al. (+5)
26 [GO] 2021―Sep―17 Synthetic Neutralizing Peptides Inhibit the Host Cell Binding of Spike Protein and Block Infection of SARS-CoV-2 Tao Wang, Xiaocui Fang, Tao Wen, Jian Liu, Zhaoyi Zhai, Zhiyou Wang, et al. (+4)
27 [GO] 2021―Sep―16 Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies Arun K. Ghosh, Jakka Raghavaiah, Dana Shahabi, Monika Yadav, Brandon J. Anson, Emma K. Lendy, et al. (+4)
28 [GO] 2021―Aug―04 Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CLpro) Sang Hoon Han, Christopher M. Goins, Tarun Arya, Woo-Jin Shin, Joshua Maw, Alice Hooper, et al. (+13)
29 [GO] 2021―Jul―30 Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein Afsaneh Sadremomtaz, Zayana M. Al-Dahmani, Angel J. Ruiz-Moreno, Alessandra Monti, Chao Wang, Taha Azad, et al. (+9)
30 [GO] 2021―Jul―19 Potent Neutralizing Antibodies Elicited by RBD-Fc-Based COVID-19 Vaccine Candidate Adjuvanted by the Th2-Skewing iNKT Cell Agonist Xi-Feng Wang, Meng-Jia Zhang, Na He, Ya-Cong Wang, Cheng Yan, Xiang-Zhao Chen, et al. (+4)
31 [GO] 2021―Jul―09 Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability Bing Bai, Alexandr Belovodskiy, Mostofa Hena, Appan Srinivas Kandadai, Michael A. Joyce, Holly A. Saffran, et al. (+20)
32 [GO] 2021―Jul―02 Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease Chamandi S. Dampalla, Yunjeong Kim, Naemi Bickmeier, Athri D. Rathnayake, Harry Nhat Nguyen, Jian Zheng, et al. (+7)
33 [GO] 2021―Apr―23 Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors Naoya Kitamura, Michael Dominic Sacco, Chunlong Ma, Yanmei Hu, Julia Alma Townsend, Xiangzhi Meng, et al. (+11)
34 [GO] 2021―Apr―22 Betulonic Acid Derivatives Interfering with Human Coronavirus 229E Replication via the nsp15 Endoribonuclease Annelies Stevaert, Besir Krasniqi, Benjamin Van Loy, Tien Nguyen, Joice Thomas, Julie Vandeput, et al. (+6)
35 [GO] 2021―Apr―19 Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2 Wenhao Dai, Dirk Jochmans, Hang Xie, Hang Yang, Jian Li, Haixia Su, et al. (+12)
36 [GO] 2021―Apr―15 Insights into SARS-CoV-2’s Mutations for Evading Human Antibodies: Sacrifice and Survival Binquan Luan, Tien Huynh
37 [GO] 2021―Mar―23 Direct Observation of Protonation State Modulation in SARS-CoV-2 Main Protease upon Inhibitor Binding with Neutron Crystallography Daniel W. Kneller, Gwyndalyn Phillips, Kevin L. Weiss, Qiu Zhang, Leighton Coates, Andrey Kovalevsky
38 [GO] 2021―Feb―03 Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models Yingjun Li, Liu Cao, Ge Li, Feng Cong, Yunfeng Li, Jing Sun, et al. (+10)
39 [GO] 2020―Dec―02 Advances toward COVID-19 Therapies Special Issue Call for Papers Hong Liu, Nouri Neamati, Nicholas Meanwell, Wendy Young, Gunda I. Georg, Shaomeng Wang
40 [GO] 2020―Nov―13 Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities Rolando Cannalire, Carmen Cerchia, Andrea R. Beccari, Francesco Saverio Di Leva, Vincenzo Summa
41 [GO] 2020―Oct―15 Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19 Robert L. Hoffman, Robert S. Kania, Mary A. Brothers, Jay F. Davies, Rose A. Ferre, Ketan S. Gajiwala, et al. (+18)
42 [GO] 2020―Aug―26 Chinese therapeutic strategy for fighting COVID-19 and potential small-molecule inhibitors against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Namrta Choudhry, Xin Zhao, Dan Xu, Mark Zanin, Weisan Chen, Zi-Feng Yang, Jianxin Chen
43 [GO] 2020―Jul―21 Lung protection by cathepsin C inhibition: a new hope for COVID-19 and ARDS? Brice Korkmaz, Adam Lesner, sylvain marchand-adam, Celia Moss, Dieter Erich Jenne
44 [GO] 2020―Jun―15 Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities Siyu Xiu, alexej dick, Han Ju, Sako Mirzaie, Fatemeh Abdi, Simon Cocklin, et al. (+2)
45 [GO] 2020―Jun―08 COVID-19: Drug targets and potential treatments Carmen Gil, Tiziana Ginex, Ines Maestro, Vanesa Nozal, Lucia Barrado-Gil, Miguel A. Cuesta-Geijo, et al. (+5)
46 [GO] 2020―Feb―27 Structure-based stabilization of non-native protein-protein interactions of coronavirus nucleocapsid proteins in antiviral drug design Shan-Meng Lin, Shih-Chao Lin, Jia-Ning Hsu, Chung-ke Chang, Ching-Ming Chien, Yong-Sheng Wang, et al. (+4)
47 [GO] 2020―Feb―11 Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication Structure-based design, synthesis, and activity assessment Linlin Zhang, Daizong Lin, Yuri Kusov, Yong Nian, Qingjun Ma, Jiang Wang, et al. (+8)
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47 Results       Page 1



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