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COVID answers in Scientific Journals all over the world

American Chemical Society: Journal of Medicinal Chemistry
  original article Date Title Authors   All Authors
1 [GO] 2022―Jan―04 Design and Evaluation of a Novel Peptide-Drug Conjugate Covalently Targeting SARS-CoV-2 Papain-like Protease Na Liu, Yichi Zhang, Yingshou Lei, Rui Wang, Meimiao Zhan, Jianbo Liu, et al. (+5)
2 [GO] 2021―Dec―05 Structure-Guided Design of Potent Inhibitors of SARS-CoV-2 3CL Protease: Structural, Biochemical, and Cell-Based Studies Chamandi S. Dampalla, Athri D. Rathnayake, Krishani Dinali Perera, Abdul-Rahman M. Jesri, Harry Nhat Nguyen, Matthew J. Miller, et al. (+9)
3 [GO] 2021―Nov―24 Stapled Peptides Targeting SARS-CoV-2 Spike Protein HR1 Inhibit the Fusion of Virus to Its Cell Receptor Mengjun Zheng, Wei Cong, Haoran Peng, Jie Qing, Huaxing Shen, Yaxin Tang, et al. (+6)
4 [GO] 2021―Nov―23 Colloidal Aggregators in Biochemical SARS-CoV-2 Repurposing Screens Henry R. O’Donnell, Tia A. Tummino, Conner Bardine, Charles S. Craik, Brian K. Shoichet
5 [GO] 2021―Nov―20 Perspectives on SARS-CoV-2 Main Protease Inhibitors Kaifu Gao, Rui Wang, Jiahui Chen, Jetze J. Tepe, Faqing Huang, Guo-Wei Wei
6 [GO] 2021―Oct―27 Structural, Electronic, and Electrostatic Determinants for Inhibitor Binding to Subsites S1 and S2 in SARS-CoV-2 Main Protease Daniel W. Kneller, Hui Li, Stephanie Galanie, Gwyndalyn Phillips, Audrey Labbé, Kevin L. Weiss, et al. (+11)
7 [GO] 2021―Oct―21 Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity Zhengnan Shen, Kiira Ratia, Laura Cooper, Deyu Kong, Hyun Lee, Youngjin Kwon, et al. (+7)
8 [GO] 2021―Oct―09 Computational Design of Potent D-Peptide Inhibitors of SARS-CoV-2 Pedro A. Valiente, Han Wen, Satra Nim, JinAh Lee, Hyeon Ju Kim, Jinhee Kim, et al. (+6)
9 [GO] 2021―Sep―27 Discovery and Mechanism of SARS-CoV-2 Main Protease Inhibitors Sarah Huff, Indrasena Reddy Kummetha, Shashi Kant Tiwari, Matthew B. Huante, Alex E. Clark, Shaobo Wang, et al. (+5)
10 [GO] 2021―Sep―17 Synthetic Neutralizing Peptides Inhibit the Host Cell Binding of Spike Protein and Block Infection of SARS-CoV-2 Tao Wang, Xiaocui Fang, Tao Wen, Jian Liu, Zhaoyi Zhai, Zhiyou Wang, et al. (+4)
11 [GO] 2021―Sep―16 Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies Arun K. Ghosh, Jakka Raghavaiah, Dana Shahabi, Monika Yadav, Brandon J. Anson, Emma K. Lendy, et al. (+4)
12 [GO] 2021―Aug―04 Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CLpro) Sang Hoon Han, Christopher M. Goins, Tarun Arya, Woo-Jin Shin, Joshua Maw, Alice Hooper, et al. (+13)
13 [GO] 2021―Jul―30 Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein Afsaneh Sadremomtaz, Zayana M. Al-Dahmani, Angel J. Ruiz-Moreno, Alessandra Monti, Chao Wang, Taha Azad, et al. (+9)
14 [GO] 2021―Jul―19 Potent Neutralizing Antibodies Elicited by RBD-Fc-Based COVID-19 Vaccine Candidate Adjuvanted by the Th2-Skewing iNKT Cell Agonist Xi-Feng Wang, Meng-Jia Zhang, Na He, Ya-Cong Wang, Cheng Yan, Xiang-Zhao Chen, et al. (+4)
15 [GO] 2021―Jul―09 Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability Bing Bai, Alexandr Belovodskiy, Mostofa Hena, Appan Srinivas Kandadai, Michael A. Joyce, Holly A. Saffran, et al. (+20)
16 [GO] 2021―Jul―02 Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3CL Protease Chamandi S. Dampalla, Yunjeong Kim, Naemi Bickmeier, Athri D. Rathnayake, Harry Nhat Nguyen, Jian Zheng, et al. (+7)
17 [GO] 2021―Apr―23 Expedited Approach toward the Rational Design of Noncovalent SARS-CoV-2 Main Protease Inhibitors Naoya Kitamura, Michael Dominic Sacco, Chunlong Ma, Yanmei Hu, Julia Alma Townsend, Xiangzhi Meng, et al. (+11)
18 [GO] 2021―Apr―22 Betulonic Acid Derivatives Interfering with Human Coronavirus 229E Replication via the nsp15 Endoribonuclease Annelies Stevaert, Besir Krasniqi, Benjamin Van Loy, Tien Nguyen, Joice Thomas, Julie Vandeput, et al. (+6)
19 [GO] 2021―Apr―19 Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2 Wenhao Dai, Dirk Jochmans, Hang Xie, Hang Yang, Jian Li, Haixia Su, et al. (+12)
20 [GO] 2021―Apr―15 Insights into SARS-CoV-2’s Mutations for Evading Human Antibodies: Sacrifice and Survival Binquan Luan, Tien Huynh
21 [GO] 2021―Mar―23 Direct Observation of Protonation State Modulation in SARS-CoV-2 Main Protease upon Inhibitor Binding with Neutron Crystallography Daniel W. Kneller, Gwyndalyn Phillips, Kevin L. Weiss, Qiu Zhang, Leighton Coates, Andrey Kovalevsky
22 [GO] 2021―Feb―03 Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models Yingjun Li, Liu Cao, Ge Li, Feng Cong, Yunfeng Li, Jing Sun, et al. (+10)
23 [GO] 2020―Dec―02 Advances toward COVID-19 Therapies Special Issue Call for Papers Hong Liu, Nouri Neamati, Nicholas Meanwell, Wendy Young, Gunda I. Georg, Shaomeng Wang
24 [GO] 2020―Nov―13 Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities Rolando Cannalire, Carmen Cerchia, Andrea R. Beccari, Francesco Saverio Di Leva, Vincenzo Summa
25 [GO] 2020―Oct―15 Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19 Robert L. Hoffman, Robert S. Kania, Mary A. Brothers, Jay F. Davies, Rose A. Ferre, Ketan S. Gajiwala, et al. (+18)
26 [GO] 2020―Aug―26 Chinese therapeutic strategy for fighting COVID-19 and potential small-molecule inhibitors against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Namrta Choudhry, Xin Zhao, Dan Xu, Mark Zanin, Weisan Chen, Zi-Feng Yang, Jianxin Chen
27 [GO] 2020―Jul―21 Lung protection by cathepsin C inhibition: a new hope for COVID-19 and ARDS? Brice Korkmaz, Adam Lesner, sylvain marchand-adam, Celia Moss, Dieter Erich Jenne
28 [GO] 2020―Jun―15 Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities Siyu Xiu, alexej dick, Han Ju, Sako Mirzaie, Fatemeh Abdi, Simon Cocklin, et al. (+2)
29 [GO] 2020―Jun―08 COVID-19: Drug targets and potential treatments Carmen Gil, Tiziana Ginex, Ines Maestro, Vanesa Nozal, Lucia Barrado-Gil, Miguel A. Cuesta-Geijo, et al. (+5)
30 [GO] 2020―Feb―27 Structure-based stabilization of non-native protein-protein interactions of coronavirus nucleocapsid proteins in antiviral drug design Shan-Meng Lin, Shih-Chao Lin, Jia-Ning Hsu, Chung-ke Chang, Ching-Ming Chien, Yong-Sheng Wang, et al. (+4)
31 [GO] 2020―Feb―11 Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication Structure-based design, synthesis, and activity assessment Linlin Zhang, Daizong Lin, Yuri Kusov, Yong Nian, Qingjun Ma, Jiang Wang, et al. (+8)


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