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COVID answers in Scientific Journals all over the world

Publishing House: American Society for Clinical Investigation

332 Results       Page 1

 [1] 
  original article Journal Date Title Authors All Authors
1 [GO] Journal of Clinical Investigation 2024―Aug―14 The forgotten pandemic: how understanding cholera illuminated mechanisms of chloride channels in multiple diseases Qais Al-Awqati
2 [GO] Journal of Clinical Investigation 2024―Jul―11 Randomised controlled trial reveals no benefit to a 3-month delay in COVID-19 mRNA booster vaccine Wen Shi Lee, Jennifer Audsley, Mai-Chi Trieu, Arnold Reynaldi, L. Carissa Aurelia, Palak H. Mehta, et al. (+15)
3 [GO] JCI Insight 2024―Jul―07 IFN-λ uniquely promotes CD8 T cell immunity against SARS-CoV-2 relative to type I IFN Abigail D. Solstad, Parker J. Denz, Adam D. Kenney, Najmus S. Mahfooz, Samuel Speaks, Qiaoke Gong, et al. (+5)
4 [GO] Journal of Clinical Investigation 2024―Jun―30 The other pandemic: lessons from 40 years of HIV research Mary E. Klotman, Barton F. Haynes
5 [GO] JCI Insight 2024―Jun―04 Factors associated with immune responses to SARS-CoV-2 vaccination in autoimmune disease individuals Erik Anderson, Michael Powell, Emily Yang, Ananya Kar, Tung Ming Leung, Cristina Sison, et al. (+28)
6 [GO] JCI Insight 2024―May―23 Prenatal SARS-CoV-2 infection results in neurodevelopmental and behavioral outcomes in mice Courtney L. McMahon, Erin M. Hurley, Aranis Muniz Perez, Manuel Estrada, Daniel J. Lodge, Jenny Hsieh
7 [GO] JCI Insight 2024―May―21 Functional and structural investigation of a broadly neutralizing SARS-CoV-2 antibody Yi-Hsuan Chang, Min-Feng Hsu, Wei-Nan Chen, Min-Hao Wu, Wye-Lup Kong, Mei-Yeh Jade Lu, et al. (+20)
8 [GO] JCI Insight 2024―May―07 Modulation of innate immune response to mRNA vaccination after SARS-CoV-2 infection or sequential vaccination in humans Fredrika Hellgren, Anja Rosdahl, Rodrigo Arcoverde Cerveira, Klara Lenart, Sebastian Ols, Yong-Dae Gwon, et al. (+9)
9 [GO] Journal of Clinical Investigation 2024―Apr―30 Integrated longitudinal multiomics study identifies immune programs associated with acute COVID-19 severity and mortality Jeremy P. Gygi, Cole Maguire, Ravi K. Patel, Pramod Shinde, Anna Konstorum, Casey P. Shannon, et al. (+37)
10 [GO] JCI Insight 2024―Apr―23 Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial Han-Sol Park, Anna Yin, Caelan Barranta, John S. Lee, Christopher A. Caputo, Jaiprasath Sachithanandham, et al. (+75)
11 [GO] JCI Insight 2024―Apr―23 Characteristics and Determinants of Pulmonary Long COVID Michael John Patton, Donald Benson, Sarah W. Robison, Dhaval Raval, Morgan L. Locy, Kinner Patel, et al. (+6)
12 [GO] JCI Insight 2024―Apr―04 Heterogeneous SARS-CoV-2 kinetics due to variable timing and intensity of immune responses Katherine Owens, Shadisadat Esmaeili, Joshua Schiffer
13 [GO] JCI Insight 2024―Apr―02 Impaired innate and adaptive immune responses to BNT162b2 SARS-CoV-2 vaccination in systemic lupus erythematosus Kavita Y. Sarin, Hong Zheng, Yashaar Chaichian, Prabhu S. Arunachalam, Gayathri Swaminathan, Alec Eschholz, et al. (+16)
14 [GO] Journal of Clinical Investigation 2024―Mar―31 Pandemics past, present, and future: progress and persistent risks Arturo Casadevall
15 [GO] JCI Insight 2024―Mar―21 A T cell-based SARS-CoV-2 spike protein vaccine provides protection without antibodies Juan Shi, Jian Zheng, Xiujuan Zhang, Wanbo Tai, Ryan Compas, Jack Deno, et al. (+10)
16 [GO] JCI Insight 2024―Mar―19 Prolonged exposure to lung-derived cytokines is associated with activation of microglia in patients with COVID-19 Rogan A. Grant, Taylor A. Poor, Lango Sichizya, Estefani Diaz, Joseph I. Bailey, Sahil Soni, et al. (+13)
17 [GO] Journal of Clinical Investigation 2024―Mar―14 Contralateral versus ipsilateral vaccine boosting for COVID-19: considering the broader scientific landscape Paul Goepfert
18 [GO] Journal of Clinical Investigation 2024―Mar―14 Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants Mengfei Chen, Andrew Pekosz, Jason S. Villano, Wenjuan Shen, Ruifeng Zhou, Heather Kulaga, et al. (+9)
19 [GO] JCI Insight 2024―Mar―12 Neutrophil proteases are protective against SARS-CoV-2 by degrading the spike protein and dampening virus-mediated inflammation Nathan G.F. Leborgne, Christelle Devisme, Nedim Kozarac, Inês Berenguer Veiga, Nadine Ebert, Aurélie Godel, et al. (+7)
20 [GO] JCI Insight 2024―Jan―11 CD3-downregulation identifies T-helper-cells with superior functionality and distinct metabolism in SARS-CoV2-vaccination- and recall-antigen-specific immunity Arne Sattler, Stefanie Gamradt, Vanessa Proß, Linda Marie Laura Thole, An He, Eva Vanessa Schrezenmeier, et al. (+5)
21 [GO] JCI Insight 2024―Jan―04 Immunoglobulin replacement products confer in vivo protection against SARS-CoV-2 XBB.1.5 Omicron variant despite poor neutralizing activity Ofer Zimmerman, Alexa Michelle Altman Doss, Baoling Ying, Chieh-Yu Liang, Samantha R. Mackin, Hannah G. Davis-Adams, et al. (+21)
22 [GO] Journal of Clinical Investigation 2023―Nov―30 High-frequency home self-collection of capillary blood correlates IFI27 expression kinetics with SARS-CoV-2 viral clearance Fang Yun Lim, Soo-Young Kim, Karisma N. Kulkarni, Rachel L. Blazevic, Louise E. Kimball, Hannah G. Lea, et al. (+9)
23 [GO] Journal of Clinical Investigation 2023―Nov―15 Cells that survive acute murine SARS-CoV-2 infection are detected nearly exclusively in the respiratory tract Ruangang Pan, David K. Meyerholz, Stanley Perlman
24 [GO] JCI Insight 2023―Nov―02 MAFB shapes human monocyte-derived macrophage response to SARS-CoV-2 and controls severe COVID-19 biomarker expression Miriam Simón-Fuentes, Israel Ríos, Cristina Herrero, Fátima Lasala, Nuria Labiod, Joanna Luczkowiak, et al. (+11)
25 [GO] Journal of Clinical Investigation 2023―Oct―10 SARS-CoV2 mRNA-vaccination-induced immunological memory in human non-lymphoid and lymphoid tissues Vanessa Proß, Arne Sattler, Söeren Lukassen, Laura Tóth, Linda Marie Laura Thole, Janine Siegle, et al. (+29)
26 [GO] JCI Insight 2023―Oct―05 Airway surveillance and lung viral control by memory T cells induced by COVID-19 mRNA vaccine Brock Kingstad-Bakke, Thomas Cleven, Hailey Bussan, Boyd L. Yount Jr., Ryuta Uraki, Kiyoko Iwatsuki-Horimoto, et al. (+10)
27 [GO] JCI Insight 2023―Sep―21 Preexisting immunity restricts mucosal antibody recognition of SARS-CoV-2 and Fc profiles during breakthrough infections Kevin J. Selva, Pradhipa Ramanathan, Ebene R. Haycroft, Arnold Reynaldi, Deborah Cromer, Chee Wah Tan, et al. (+12)
28 [GO] JCI Insight 2023―Sep―12 Mild/asymptomatic COVID-19 in unvaccinated pregnant mothers impairs neonatal immune responses Brianna M. Doratt, Suhas Sureshchandra, Heather True, Monica Rincon, Nicole E. Marshall, Ilhem Messaoudi
29 [GO] Journal of Clinical Investigation 2023―Sep―05 Vaccine effectiveness of BNT162b2 mRNA Covid-19 vaccine in children under 5 years Christoph Strumann, Otavio T. Ranzani, Jeanne Moor, Reinhard Berner, Nicole Toepfner, Cho-Ming Chao, Matthias B. Moor
30 [GO] JCI Insight 2023―Aug―21 Key patient demographics shape innate immune topography in noncritical hypoxic COVID-19 pneumonia Allison C. Billi, Rachael Wasikowski, Feiyang Ma, Srilakshmi Yalavarthi, Claire K. Hoy, Yu Zuo, et al. (+15)
31 [GO] JCI Insight 2023―Aug―21 Prior cycles of anti-CD20 antibodies affect antibody responses after repeated SARS-CoV-2 mRNA vaccination Hiromitsu Asashima, Dongjoo Kim, Kaicheng Wang, Nikhil Lele, Nicholas C. Buitrago-Pocasangre, Rachel Lutz, et al. (+17)
32 [GO] Journal of Clinical Investigation 2023―Aug―15 Adverse outcomes in SARS-CoV-2 infected pregnant mice are gestational age-dependent and resolve with antiviral treatment Patrick S. Creisher, Jamie L. Perry, Weizhi Zhong, Jun Lei, Kathleen R. Mulka, W. Hurley Ryan, et al. (+7)
33 [GO] Journal of Clinical Investigation 2023―Aug―10 Mast cell activation in lungs during SARS-CoV-2 infection associated with lung pathology and severe COVID-19 Janessa Yan Jun Tan, Danielle E. Anderson, Abhay P.S. Rathore, Aled O'Neill, Chinmay Kumar Mantri, Wilfried A.A. Saron, et al. (+13)
34 [GO] JCI Insight 2023―Jul―25 Balance between maternal antiviral response and placental transfer of protection in gestational SARS-CoV-2 infection Juliana Gonçalves, Magda Melro, Marta Alenquer, Catarina Araújo, Júlia Castro-Neves, Daniela Amaral-Silva, et al. (+7)
35 [GO] Journal of Clinical Investigation 2023―Jul―20 No evidence of durable trained immunity after two doses of adenovirus-vectored or mRNA COVID-19 vaccines Natalie E. Stevens, Feargal J. Ryan, Nicole L. Messina, Stephen J. Blake, Todd S. Norton, Susie Germano, et al. (+8)
36 [GO] JCI Insight 2023―Jun―20 Anti-S1 and S2 antibodies from hybrid immunity elicit potent cross-variant ADCC against SARS-CoV-2 Michael D. Grant, Kirsten Bentley, Ceri A. Fielding, Keeley M. Hatfield, Danielle P. Ings, Debbie Harnum, et al. (+3)
37 [GO] JCI Insight 2023―Jun―20 Diminished responses to mRNA-based SARS-CoV-2 vaccines in individuals with rheumatoid arthritis on immune modifying therapies Samuel D Klebanoff, Lauren B. Rodda, Chihiro Morishima, Mark H. Wener, Yevgeniy Yuzefpolskiy, Estelle Bettelli, et al. (+4)
38 [GO] JCI Insight 2023―Jun―07 Autoantigen profiling reveals a shared post-COVID signature in fully recovered and long COVID patients Aaron Bodansky, Chung-Yu Wang, Aditi Saxena, Anthea Mitchell, Andrew F. Kung, Saki Takahashi, et al. (+21)
39 [GO] JCI Insight 2023―Jun―01 Modeling of ACE2 and antibodies bound to SARS-CoV-2 provides insights into infectivity and immune evasion Joseph H. Lubin, Christopher Markosian, D. Balamurugan, Minh T. Ma, Chih-Hsiung Chen, Dongfang Liu, et al. (+4)
40 [GO] JCI Insight 2023―May―30 Qualitative monitoring of SARS-CoV-2 mRNA vaccination in humans using droplet microfluidics Matteo Broketa, Aurélien Sokal, Michael Mor, Pablo Canales-Herrerias, Angga Perima, Annalisa Meola, et al. (+15)
41 [GO] JCI Insight 2023―May―25 A modeling-based approach to optimize COVID-19 vaccine dosing schedules for improved protection Prashant Dogra, Carmine Schiavone, Zhihui Wang, Javier Ruiz-Ramírez, Sergio Caserta, Daniela I. Staquicini, et al. (+6)
42 [GO] Journal of Clinical Investigation 2023―May―23 Prevalence and functional profile of SARS-CoV-2 T cells in asymptomatic Kenyan adults Taraz Samandari, Joshua Ongalo, Kimberly McCarthy, Richard K. Biegon, Philister Madiega, Anne Mithika, et al. (+15)
43 [GO] JCI Insight 2023―May―21 Marked elevations in lung and plasma ceramide in COVID-19 linked to microvascular injury Irina Petrache, Elisabet Pujadas, Aditya Ganju, Karina A. Serban, Alexander Borowiec, Beatrice Babbs, et al. (+8)
44 [GO] JCI Insight 2023―May―09 T cell responses to SARS-CoV-2 vaccination differ by disease-modifying therapy for multiple sclerosis Asia-Sophia Wolf, Anthony Ravussin, Marton König, Mathias H. Øverås, Guri Solum, Ingrid Fadum Kjønstad, et al. (+12)
45 [GO] Journal of Clinical Investigation 2023―Apr―27 Machine learning links unresolving secondary pneumonia to mortality in patients with severe pneumonia, including COVID-19 Catherine A. Gao, Nikolay S. Markov, Thomas Stoeger, Anna E. Pawlowski, Mengjia Kang, Prasanth Nannapaneni, et al. (+14)
46 [GO] Journal of Clinical Investigation 2023―Apr―27 C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps Bruna M.S. Silva, Giovanni F. Gomes, Flavio P. Veras, Seppe Cambier, Gabriel V.L. Silva, Andreza U. Quadros, et al. (+38)
47 [GO] Journal of Clinical Investigation 2023―Apr―16 Does the SARS-CoV-2 spike really have an Achilles heel? Shiv Pillai
48 [GO] Journal of Clinical Investigation 2023―Apr―13 Biological rhythms in COVID-19 vaccine effectiveness in an observational cohort study of 1.5 million patients Guy Hazan, Or A. Duek, Hillel Alapi, Huram Mok, Alexander T. Ganninger, Elaine M. Ostendorf, et al. (+4)
49 [GO] JCI Insight 2023―Apr―11 Cytokine storm based mechanisms for extra-pulmonary manifestations of SARS-CoV-2 infection Maria Del Nogal Avila, Ranjan Das, Joubert B. Kharlyngdoh, Eduardo Molina-Jijon, Hector Donoro-Blazquez, Stéphanie Gambut, et al. (+9)
50 [GO] JCI Insight 2023―Apr―09 Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations Jennifer R. Habel, Brendon Y. Chua, Lukasz Kedzierski, Kevin J. Selva, Timon Damelang, Ebene R. Haycroft, et al. (+48)
51 [GO] JCI Insight 2023―Apr―09 Single-epitope T cell-based vaccine protects against SARS-CoV-2 infection in a preclinical animal model Takuya Tada, Ju-Yi Peng, Belinda M. Dcosta, Nathaniel R. Landau
52 [GO] Journal of Clinical Investigation 2023―Mar―23 Durability of immune responses to the booster mRNA vaccination against COVID-19 Prabhu S Arunachalam, Lilin Lai, Hady Samaha, Yupeng Feng, Mengyun Hu, Harold Sai-yin Hui, et al. (+15)
53 [GO] Journal of Clinical Investigation 2023―Mar―14 SARS-CoV-2 variants resistant to monoclonal antibodies in immunocompromised patients is a public health concern Arturo Casadevall, Daniele Focosi
54 [GO] JCI Insight 2023―Mar―07 Short- and long-term T cell and antibody responses following Dexamethasone treatment in COVID-19 Charlotte Thibeault, Lara Bardtke, Kanika Vanshylla, Veronica Cristianzano, Kirsten A. Eberhardt, Paula Stubbemann, et al. (+14)
55 [GO] JCI Insight 2023―Mar―02 COVID-19 convalescent plasma boosts early antibody titer and does not influence the adaptive immune response John F. McDyer, Mahzad Azimpouran, Valerie L. Durkalski-Mauldin, Robert G. Clevenger, Sharon D. Yeatts, Xutao Deng, et al. (+13)
56 [GO] Journal of Clinical Investigation 2023―Mar―02 Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody to antigenically distinct Omicron subvariants Siriruk Changrob, Peter J. Halfmann, Hejun Liu, Jonathan L. Torres, Joshua J.C. McGrath, Gabriel Ozorowski, et al. (+21)
57 [GO] Journal of Clinical Investigation 2023―Feb―23 Therapeutic potential of convalescent plasma and SARS-CoV-2 hyperimmune immunoglobulins against BQ.1, BQ.1.1 and XBB variants Lorenza Bellusci, Hana Golding, Surender Khurana
58 [GO] JCI Insight 2023―Feb―20 Impact of host factors and COVID-19 infection on the humoral immune repertoire in treated HIV Samuel R. Schnittman, Wonyeong Jung, Kathleen V. Fitch, Markella V. Zanni, Sara McCallum, Jessica Shih-Lu Lee, et al. (+16)
59 [GO] JCI Insight 2023―Feb―07 A specific molecular signature in SARS-CoV-2 infected kidney biopsies Pierre Isnard, Paul Vergnaud, Serge Garbay, Matthieu Jamme, Maeva Eloudzeri, Alexandre Karras, et al. (+17)
60 [GO] JCI Insight 2023―Feb―07 Selective suppression of de novo SARS-CoV2 vaccine antibody responses in cancer patients on B cell-targeted therapy Joseph H. Azar, John P. Evans, Madison H. Sikorski, Karthik B. Chakravarthy, Selah McKenney, Ian Carmody, et al. (+23)
61 [GO] Journal of Clinical Investigation 2023―Feb―02 Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments Akshita Gupta, Angelina Konnova, Mathias Smet, Matilda Berkell, Alessia Savoldi, Matteo Morra, et al. (+10)
62 [GO] Journal of Clinical Investigation 2023―Jan―31 Unlocking life-threatening COVID-19 through two types of inborn errors of type I IFNs Jean-Laurent Casanova, Mark S. Anderson
63 [GO] JCI Insight 2023―Jan―26 An extended interval between vaccination and infection enhances hybrid immunity against SARS-CoV-2 variants Timothy A. Bates, Hans C. Leier, Savannah K. McBride, Devin Schoen, Zoe L. Lyski, David D. Xthona Lee, et al. (+3)
64 [GO] Journal of Clinical Investigation 2023―Jan―16 Beyond adaptive immunity: induction of trained immunity by COVID-19 adenoviral vaccines Mihai G. Netea, Leo A.B. Joosten
65 [GO] JCI Insight 2023―Jan―09 Mucociliary transport deficiency and disease progression in Syrian hamsters with SARS-CoV-2 infection Qian Li, Kadambari Vijaykumar, Scott E. Phillips, Shah S. Hussain, Nha V. Huynh, Courtney M. Fernandez-Petty, et al. (+20)
66 [GO] Journal of Clinical Investigation 2023―Jan―02 Impact of antigenic evolution and original antigenic sin on SARS-CoV-2 immunity Muriel Aguilar-Bretones, Ron A.M. Fouchier, Marion P.G. Koopmans, Gijsbert P. van Nierop
67 [GO] JCI Insight 2022―Dec―27 Combined molnupiravir-nirmatrelvir treatment improves effect on SARS-CoV-2 in Macaques Kyle Rosenke, Matthew C. Lewis, Friederike Feldmann, Eric Bohrnsen, Benjamin Schwarz, Atsushi Okumura, et al. (+8)
68 [GO] JCI Insight 2022―Dec―06 Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury Amy R. Cross, Carlos E. de Andrea, María Villalba-Esparza, Manuel F. Landecho, Lucia Cerundolo, Praveen Weeratunga, et al. (+10)
69 [GO] Journal of Clinical Investigation 2022―Dec―01 Impact of pre-existing chronic viral infection and reactivation on the development of long COVID Michael J. Peluso, Tyler-Marie Deveau, Sadie E. Munter, Dylan M. Ryder, Amanda M. Buck, Gabriele Beck-Engeser, et al. (+26)
70 [GO] Journal of Clinical Investigation 2022―Nov―30 Omicron infection elicits a broad neutralizing response in hospitalized patients with COVID-19 Elizabeth M. McNally
71 [GO] JCI Insight 2022―Nov―29 Longitudinal single-cell analysis of SARS-CoV-2-reactive B cells uncovers persistence of early-formed, antigen specific clones Lydia Scharf, Hannes Axelsson, Aikaterini Emmanouilidi, Nimitha R. Mathew, Daniel J. Sheward, Susannah Leach, et al. (+10)
72 [GO] JCI Insight 2022―Nov―21 Severe acute respiratory disease in American mink experimentally infected with SARS-CoV-2 Danielle R. Adney, Jamie Lovaglio, Jonathan E. Schulz, Claude Kwe Yinda, Victoria A. Avanzato, Elaine Haddock, et al. (+16)
73 [GO] JCI Insight 2022―Nov―15 Bamlanivimab therapy for acute COVID-19 does not blunt SARS-CoV-2-specific memory T cell responses Sydney I. Ramirez, Alba Grifoni, Daniela Weiskopf, Urvi M. Parikh, Amy Heaps, Farhoud Faraji, et al. (+13)
74 [GO] JCI Insight 2022―Nov―15 SARS-CoV-2 infection of sustentacular cells disrupts olfactory signaling pathways Abhishek Kumar Verma, Jian Zheng, David K. Meyerholz, Stanley Perlman
75 [GO] Journal of Clinical Investigation 2022―Nov―03 One-year follow-up of the CAPSID randomized trial for high-dose convalescent plasma in severe COVID-19 patients Sixten Körper, Beate Grüner, Daniel Zickler, Thomas Wiesmann, Patrick Wuchter, Rainer Blasczyk, et al. (+34)
76 [GO] Journal of Clinical Investigation 2022―Oct―27 Stabilized recombinant SARS-CoV-2 spike antigen enhances vaccine immunogenicity and protective capacity Christian Meyer zu Natrup, Alina Tscherne, Christine Dahlke, Malgorzata Ciurkiewicz, Dai-Lun Shin, Anahita Fathi, et al. (+27)
77 [GO] Journal of Clinical Investigation 2022―Oct―25 Trained immunity is induced in humans after immunization with an adenoviral vector COVID-19 vaccine Dearbhla M. Murphy, Donal J. Cox, Sarah A. Connolly, Eamon P Breen, Aenea A.I. Brugman, James J. Phelan, et al. (+2)
78 [GO] Journal of Clinical Investigation 2022―Oct―25 The Notch1/CD22 signaling axis disrupts Treg cell function in SARS-CoV2-associated multisystem inflammatory syndrome in children Mehdi Benamar, Qian Chen, Janet Chou, Amélie M. Julé, Rafik Boudra, Paola Contini, et al. (+44)
79 [GO] Journal of Clinical Investigation 2022―Oct―20 Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2 Guoli Shi, Abhilash I. Chiramel, Tiansheng Li, Kin Kui Lai, Adam D. Kenney, Ashley Zani, et al. (+10)
80 [GO] Journal of Clinical Investigation 2022―Oct―18 Neutralizing antibody responses in patients hospitalized with SARS-CoV-2 Delta or Omicron infection Susanne L. Linderman, Lilin Lai, Estefany L. Bocangel Gamarra, Max S.Y. Lau, Srilatha Edupuganti, Diya Surie, et al. (+16)
81 [GO] Journal of Clinical Investigation 2022―Oct―11 Improved control of SARS-CoV-2 by treatment with nucleocapsid-specific monoclonal antibody Tanushree Dangi, Sarah Sanchez, Jacob Class, Michelle C. Richner, Lavanya Visvabharathy, Young Rock Chung, et al. (+5)
82 [GO] JCI Insight 2022―Oct―09 Vaccine breakthrough infection leads to distinct profiles of neutralizing antibody responses by SARS-CoV-2 variant Michael S. Seaman, Mark J. Siedner, Julie Boucau, Christy L. Lavine, Fadi Ghantous, May Y. Liew, et al. (+23)
83 [GO] Journal of Clinical Investigation 2022―Sep―27 Recognizing the importance of COVID-19 data wrangling Laura J. Rasmussen-Torvik
84 [GO] JCI Insight 2022―Sep―22 Lower SARS-CoV-2 specific humoral immunity in People Living with HIV-1 recovered from non-hospitalized COVID-19 Daniel J. Schuster, Shelly Karuna, Caroline Brackett, Martina S. Wesley, Shuying S. Li, Nathan Eisel, et al. (+18)
85 [GO] JCI Insight 2022―Sep―21 Cross-reactivity of SARS-CoV-2- and influenza A-specific T cells in individuals exposed to SARS-CoV-2 Worarat Chaisawangwong, Hanzhi Wang, Theodore Kouo, Sebastian F. Salathe, Ariel Isser, Joan Glick Bieler, et al. (+8)
86 [GO] JCI Insight 2022―Sep―21 Markers of fungal translocation are elevated during post-acute sequelae of SARS-CoV-2 and induce NF-κB signaling Leila B. Giron, Michael J. Peluso, Jianyi Ding, Grace Kenny, Netanel F. Zilberstein, Jane Koshy, et al. (+23)
87 [GO] Journal of Clinical Investigation 2022―Sep―14 Durability of protection and immunogenicity of AZD1222 (ChAdOx1 nCoV-19) COVID-19 vaccine over 6 months Magdalena E. Sobieszczyk, Jill Maaske, Ann R. Falsey, Stephanie Sproule, Merlin L. Robb, Robert W. Frenck, et al. (+17)
88 [GO] Journal of Clinical Investigation 2022―Sep―14 Lessons from a large-scale COVID-19 vaccine trial Ranjeet Singh Mahla, Lynn B. Dustin
89 [GO] JCI Insight 2022―Sep―01 SARS-CoV-2 reinfections during the Delta and Omicron waves C. Paul Morris, Raghda E. Eldesouki, Amary Fall, David C. Gaston, Julie M. Norton, Nicholas D. Gallagher, et al. (+4)
90 [GO] Journal of Clinical Investigation 2022―Aug―31 COVID-19 vaccines protect children of all ages Justin Z. Amarin, Haya Hayek, Natasha B. Halasa
91 [GO] JCI Insight 2022―Aug―09 Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in elderly people Joana Vitallé, Alberto Pérez-Gómez, Francisco José Ostos, Carmen Gasca-Capote, Maria Reyes Jiménez-Leon, Sara Bachiller, et al. (+7)
92 [GO] Journal of Clinical Investigation 2022―Aug―09 NVX-CoV2373 vaccination induces functional SARS-CoV-2-specific CD4+ and CD8+ T cell responses Carolyn Rydyznski Moderbacher, Christina J. Kim, Jose Mateus, Joyce S. Plested, Mingzhu Zhu, Shane Cloney-Clark, et al. (+5)
93 [GO] Journal of Clinical Investigation 2022―Jul―31 Long COVID endotheliopathy: hypothesized mechanisms and potential therapeutic approaches Jasimuddin Ahamed, Jeffrey Laurence
94 [GO] JCI Insight 2022―Jul―19 Multicenter analysis of neutrophil extracellular trap dysregulation in adult and pediatric COVID-19 Carmelo Carmona-Rivera, Yu Zhang, Kerry Dobbs, Tovah E. Markowitz, Clifton L. Dalgard, Andrew J. Oler, et al. (+47)
95 [GO] Journal of Clinical Investigation 2022―Jul―14 Frequent detection but lack of infectivity of SARS-CoV-2 RNA in pre-symptomatic, infected blood donor plasma Paula Saá, Rebecca V. Fink, Sonia Bakkour, Jing Jin, Graham Simmons, Marcus O. Muench, et al. (+19)
96 [GO] JCI Insight 2022―Jun―21 Markers of fungal translocation are elevated during post-acute sequelae of SARS-CoV-2 and induce NF-κB signaling Leila B. Giron, Michael J. Peluso, Jianyi Ding, Grace Kenny, Netanel F. Zilberstein, Jane Koshy, et al. (+23)
97 [GO] JCI Insight 2022―Jun―21 Biochemical, biophysical, and immunological characterization of respiratory secretions in severe SARS-CoV-2 infections Michael J. Kratochvil, Gernot Kaber, Sally Demirdjian, Pamela C. Cai, Elizabeth B. Burgener, Nadine Nagy, et al. (+20)
98 [GO] JCI Insight 2022―Jun―21 Boosting corrects a memory B cell defect in SARS-CoV-2 mRNA-vaccinated patients with inflammatory bowel disease Kathryn A. Pape, Thamotharampillai Dileepan, William E. Matchett, Charles Ellwood, Samuel Stresemann, Amanda J. Kabage, et al. (+14)
99 [GO] JCI Insight 2022―Jun―02 mRNA-1273 vaccination protects against SARS-CoV-2 elicited lung inflammation in non-human primates Adam T. Waickman, Kaitlin Victor, Krista Newell, Tao Li, Heather Friberg, Kathryn E. Foulds, et al. (+4)
100 [GO] JCI Insight 2022―May―24 Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses Anna L. McNaughton, Robert S. Paton, Matthew Edmans, Jonathan C.W. Youngs, Judith Wellens, Prabhjeet Phalora, et al. (+48)
101 [GO] JCI Insight 2022―May―17 Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination Yusuke Matsui, Lin Li, Mary Prahl, Arianna G. Cassidy, Nida Ozarslan, Yarden Golan, et al. (+29)
102 [GO] JCI Insight 2022―May―17 Molnupiravir inhibits SARS-CoV-2 variants including Omicron in the hamster model Kyle Rosenke, Atsushi Okumura, Matthew C. Lewis, Friederike Feldmann, Kimberly Meade-White, William F. Bohler, et al. (+5)
103 [GO] JCI Insight 2022―May―10 Phase 1 trial of cyclosporine for hospitalized patients with COVID-19 Emily A. Blumberg, Julia Han Noll, Pablo Tebas, Joseph A. Fraietta, Ian Frank, Amy E. Marshall, et al. (+17)
104 [GO] Journal of Clinical Investigation 2022―May―10 Favorable vaccine-induced SARS-CoV-2 specific T cell response profile in patients undergoing immune-modifying therapies Martin Qui, Nina Le Bert, Webber Pak Wo Chan, Malcolm Tan, Shou Kit Hang, Smrithi Hariharaputran, et al. (+7)
105 [GO] JCI Insight 2022―Apr―28 Lethal synergy between SARS-CoV-2 and Streptococcus pneumoniae in hACE2 mice and protective efficacy of vaccination Tarani Kanta Barman, Amit K. Singh, Jesse L. Bonin, Tanvir N. Nafiz, Sharon L. Salmon, Dennis W. Metzger
106 [GO] Journal of Clinical Investigation 2022―Apr―28 Antibodies from convalescent plasma promote SARS-CoV-2 clearance in individuals with and without endogenous antibody response Maddalena Marconato, Irene A. Abela, Anthony Hauser, Magdalena Schwarzmüller, Rheliana Katzensteiner, Dominique L. Braun, et al. (+17)
107 [GO] JCI Insight 2022―Apr―26 JAK inhibitor blocks COVID-19-cytokine-induced JAK-STAT-APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids Sarah E. Nystrom, Guojie Li, Somenath Datta, Karen Soldano, Daniel Silas, Astrid Weins, et al. (+3)
108 [GO] Journal of Clinical Investigation 2022―Apr―26 An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimer Naveenchandra Suryadevara, Andrea R. Shiakolas, Laura A. VanBlargan, Elad Binshtein, Rita E. Chen, James Brett Case, et al. (+15)
109 [GO] JCI Insight 2022―Apr―26 Accelerated waning of immunity to SARS-CoV-2 mRNA vaccines in patients with immune mediated inflammatory diseases Roya M. Dayam, Jaclyn C. Law, Rogier L. Goetgebuer, Gary Y.C. Chao, Kento T. Abe, Mitchell Sutton, et al. (+26)
110 [GO] JCI Insight 2022―Apr―21 Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19 Michael Chait, Mine M. Yilmaz, Shanila Shakil, Amy W. Ku, Pranay Dogra, Thomas J. Connors, et al. (+12)
111 [GO] JCI Insight 2022―Apr―21 Bacillus Calmette-Guérin-induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 mice Bao-Zhong Zhang, Huiping Shuai, Hua-rui Gong, Jing-Chu Hu, Bingpeng Yan, Terrence Tsz-Tai Yuen, et al. (+19)
112 [GO] JCI Insight 2022―Apr―19 Longitudinal analysis of T-cell receptor repertoires reveals shared patterns of antigen-specific response to SARS-CoV-2 infection Rachel M. Gittelman, Enrico Lavezzo, Thomas M. Snyder, H. Jabran Zahid, Cara L. Carty, Rebecca Elyanow, et al. (+23)
113 [GO] JCI Insight 2022―Apr―19 T-cell receptor sequencing identifies prior SARS-CoV-2 infection and correlates with neutralizing antibodies and disease severity Rebecca Elyanow, Thomas M. Snyder, Sudeb C. Dalai, Rachel M. Gittelman, Jim Boonyaratanakornkit, Anna Wald, et al. (+16)
114 [GO] JCI Insight 2022―Apr―07 Immunogenic epitope panel for accurate detection of non-cross-reactive T cell response to SARS-CoV-2 Aleksei Titov, Regina Shaykhutdinova, Olga V. Shcherbakova, Yana V. Serdyuk, Savely A. Sheetikov, Ksenia V. Zornikova, et al. (+17)
115 [GO] JCI Insight 2022―Apr―07 SARS-CoV-2 -specific immune responses in boosted vaccine recipients with breakthrough infections during the Omicron variant surge Bezawit A. Woldemeskel, Caroline C. Garliss, Tihitina Y. Aytenfisu, Trevor S. Johnston, Evan J. Beck, Arbor G. Dykema, et al. (+9)
116 [GO] JCI Insight 2022―Apr―07 Role of antibodies, inflammatory markers, and echocardiographic findings in post-acute cardiopulmonary symptoms after SARS-CoV-2 infection Matthew S. Durstenfeld, Michael J. Peluso, J. Daniel Kelly, Sithu Win, Shreya Swaminathan, Danny Li, et al. (+18)
117 [GO] JCI Insight 2022―Apr―05 Functional reprogramming of monocytes in acute and convalescent severe COVID-19 patients Elisa Brauns, Abdulkader Azouz, David Grimaldi, Hanxi Xiao, Séverine Thomas, Muriel Nguyen, et al. (+11)
118 [GO] JCI Insight 2022―Mar―29 IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function Livia Casciola-Rosen, David R. Thiemann, Felipe Andrade, Maria I. Trejo-Zambrano, Elissa K. Leonard, Jamie B. Spangler, et al. (+32)
119 [GO] JCI Insight 2022―Mar―29 Temporary antimetabolite treatment hold boosts SARS-CoV-2 vaccination-specific humoral and cellular immunity in kidney transplant recipients Eva Schrezenmeier, Hector Rincon-Arevalo, Annika Jens, Ana-Luisa Stefanski, Charlotte Hammett, Bilgin Osmanodja, et al. (+23)
120 [GO] JCI Insight 2022―Mar―22 Binding and neutralizing antibody responses to SARS-CoV-2 in young children exceed those in adults Ruth A. Karron, Maria Garcia Quesada, Elizabeth A. Schappell, Stephen D. Schmidt, Maria Deloria Knoll, Marissa K. Hetrich, et al. (+3)
121 [GO] Journal of Clinical Investigation 2022―Mar―22 A multitope SARS-COV-2 vaccine provides long-lasting B cell and T cell immunity against Delta and Omicron variants Chang Yi Wang, Kao-Pin Hwang, Hui-Kai Kuo, Wen-Jiun Peng, Yea-Huei Shen, Be-Sheng Kuo, et al. (+44)
122 [GO] JCI Insight 2022―Mar―17 RAGE has potential pathogenetic and prognostic value in non-intubated hospitalized patients with COVID-19 Katherine D. Wick, Lianne Siegel, James D. Neaton, Cathryn Oldmixon, Jens Lundgren, Robin L. Dewar, et al. (+3)
123 [GO] JCI Insight 2022―Mar―15 Monoclonal antibody targeting the conserved region of the SARS-CoV-2 spike protein to overcome viral variants Wan-Ling Wu, Chen-Yi Chiang, Szu-Chia Lai, Chia-Yi Yu, Yu-Ling Huang, Hung-Chun Liao, et al. (+3)
124 [GO] Journal of Clinical Investigation 2022―Mar―08 Vaccine-breakthrough infections with SARS-CoV-2 Alpha mirror mutations in Delta Plus, Iota and Omicron Brenda Martínez-González, Lucía Vázquez-Sirvent, María E. Soria, Pablo Mínguez, Llanos Salar-Vidal, Carlos García-Crespo, et al. (+13)
125 [GO] JCI Insight 2022―Mar―01 In-depth analysis of SARS-CoV-2-specific T cells reveals diverse differentiation hierarchies in vaccinated individuals Li Li, Muharrem Muftuoglu, Shaoheng Liang, Mahesh Basyal, Jiangxing LV, Mehmet E. Akdogan, et al. (+3)
126 [GO] JCI Insight 2022―Feb―22 Durability of ChAdOx1 nCov-19 vaccination in people living with HIV Ane Ogbe, Matthew Pace, Mustapha Bittaye, Timothy Tipoe, Sandra Adele, Jasmini Alagaratnam, et al. (+52)
127 [GO] JCI Insight 2022―Feb―21 Long-term follow-up of dynamic brain changes in patients recovered from COVID-19 without neurological manifestations Tian Tian, Jinfeng Wu, Tao Chen, Jia Li, Su Yan, Yiran Zhou, et al. (+10)
128 [GO] JCI Insight 2022―Feb―17 Temporal transcriptomic analysis using TrendCatcher identifies early and persistent neutrophil activation in severe COVID-19 Xinge Wang, Mark A. Sanborn, Yang Dai, Jalees Rehman
129 [GO] Journal of Clinical Investigation 2022―Feb―09 Streptococcus pneumoniae colonization associates with impaired adaptive immune responses against SARS-CoV-2 Elena Mitsi, Jesús Reiné, Britta C. Urban, Carla Solorzano, Elissavet Nikolaou, Angela D. Hyder-Wright, et al. (+24)
130 [GO] Journal of Clinical Investigation 2022―Feb―09 SARS-CoV-2 infection and vaccination trigger long-lived B and CD4+ T lymphocytes: implications for booster strategies Alessio Mazzoni, Anna Vanni, Michele Spinicci, Giulia Lamacchia, Seble Tekle Kiros, Arianna Rocca, et al. (+15)
131 [GO] JCI Insight 2022―Feb―08 T cell response to intact SARS-CoV-2 includes coronavirus cross-reactive and variant-specific components Lichen Jing, Xia Wu, Maxwell P. Krist, Tien-Ying Hsiang, Victoria L. Campbell, Christopher L. McClurkan, et al. (+13)
132 [GO] JCI Insight 2022―Feb―08 Disulfiram inhibits neutrophil extracellular trap formation protecting rodents from acute lung injury and SARS-CoV-2 infection Jose M. Adrover, Lucia Carrau, Juliane Daßler-Plenker, Yaron Bram, Vasuretha Chandar, Sean Houghton, et al. (+7)
133 [GO] Journal of Clinical Investigation 2022―Feb―02 Ultrapotent neutralizing antibodies against SARS-CoV-2 with a high degree of mutation resistance Jia Zou, Li Li, Peiyi Zheng, Wenhua Liang, Siyi Hu, Shuaixiang Zhou, et al. (+28)
134 [GO] JCI Insight 2022―Feb―01 Adaptive immune responses in vaccinated patients with symptomatic SARS-CoV-2 Alpha infection Han-Sol Park, Janna R. Shapiro, Ioannis Sitaras, Bezawit A. Woldemeskel, Caroline Garliss, Amanda Dziedzic, et al. (+32)
135 [GO] JCI Insight 2022―Jan―24 Impairing RAGE signaling promotes survival and limits disease pathogenesis following SARS-CoV-2 infection in mice Forrest Jessop, Benjamin Schwarz, Dana Scott, Lydia M. Roberts, Eric Bohrnsen, John R. Hoidal, Catharine M. Bosio
136 [GO] Journal of Clinical Investigation 2022―Jan―21 CD4+ T-cells from COVID-19 mRNA vaccine recipients recognize a conserved epitope present in diverse coronaviruses Bezawit A. Woldemeskel, Arbor G. Dykema, Caroline Garliss, Saphira Cherfils, Kellie N. Smith, Joel N. Blankson
137 [GO] JCI Insight 2022―Jan―19 Limited induction of SARS-CoV-2-specific T cell responses in children with multisystem inflammatory syndrome compared to COVID-19 Vidisha Singh, Veronica Obregon-Perko, Stacey A. Lapp, Anna M. Horner, Alyssa Brooks, Lisa Macoy, et al. (+10)
138 [GO] JCI Insight 2022―Jan―14 Multiple sclerosis therapies differentially impact SARS-CoV-2 vaccine-induced antibody and T cell immunity and function Joseph J. Sabatino Jr, Kristen Mittl, William M. Rowles, Kira McPolin, Jayant V. Rajan, Matthew T. Laurie, et al. (+14)
139 [GO] JCI Insight 2022―Jan―12 SARS-CoV-2 BNT162b2 vaccine-induced humoral response and reactogenicity in individuals with prior COVID-19 disease Steven G. Kelsen, Alan S. Braverman, Mark O. Aksoy, Jacob A. Hayman, Puja S. Patel, Charu Rajput, et al. (+4)
140 [GO] Journal of Clinical Investigation 2021―Dec―29 Platelets mediate inflammatory monocyte activation by SARS-CoV-2 Spike protein Tianyang Li, Yang Yang, Yongqi Li, Zhengmin Wang, Faxiang Ma, Runqi Luo, et al. (+7)
141 [GO] JCI Insight 2021―Dec―21 Single-cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine Suhas Sureshchandra, Sloan A. Lewis, Brianna M. Doratt, Allen Jankeel, Izabela Coimbra Ibraim, Ilhem Messaoudi
142 [GO] JCI Insight 2021―Dec―15 A functionally distinct neutrophil landscape in severe COVID-19 reveals opportunities for adjunctive therapies Rachita Panda, Fernanda V.S. Castanheira, Jared M. Schlechte, Bas G.J. Surewaard, Hanjoo Brian Shim, Amanda Z. Zucoloto, et al. (+4)
143 [GO] Journal of Clinical Investigation 2021―Dec―14 The Journal of Clinical Investigation in the time of COVID-19 Arturo Casadevall, Sarah Jackson, Gregg L. Semenza, Gordon F. Tomaselli, Rexford S. Ahima
144 [GO] JCI Insight 2021―Dec―14 Clinico-histopathologic and single nuclei RNA sequencing insights into cardiac injury and microthrombi in critical COVID-19 Michael I. Brener, Michelle L. Hulke, Nobuaki Fukuma, Stephanie Golob, Robert S. Zilinyi, Zhipeng Zhou, et al. (+19)
145 [GO] Journal of Clinical Investigation 2021―Dec―14 Difference in sensitivity between SARS-CoV-2-specific T cell assays in patients with underlying conditions. Reply. Anthony T. Tan, Nina Le Bert, Antonio Bertoletti
146 [GO] Journal of Clinical Investigation 2021―Dec―14 Difference in sensitivity between SARS-CoV-2-specific T cell assays in patients with underlying conditions Rory D. de Vries, Marieke van der Heiden, Daryl Geers, Celine Imhof, Debbie van Baarle
147 [GO] Journal of Clinical Investigation 2021―Dec―06 Randomized, double-blind, controlled trial of human anti-LIGHT monoclonal antibody in COVID-19 acute respiratory distress syndrome David S. Perlin, Garry A. Neil, Colleen Anderson, Inbal Zafir-Lavie, Shane Raines, Carl F. Ware, H. Jeffrey Wilkins
148 [GO] JCI Insight 2021―Dec―06 Duration of viral shedding and culture positivity with post-vaccination SARS-CoV-2 delta variant infections Mark J. Siedner, Julie Boucau, Rebecca F. Gilbert, Rockib Uddin, Jonathan Luu, Sebastien Haneuse, et al. (+14)
149 [GO] Journal of Clinical Investigation 2021―Nov―29 SARS-CoV-2-specific memory B cells can persist in the elderly who have lost detectable neutralising antibodies Anna Jeffery-Smith, Alice R. Burton, Sabela Lens, Chloe Rees-Spear, Jessica Davies, Monika Patel, et al. (+9)
150 [GO] JCI Insight 2021―Nov―22 Sangivamycin is highly effective against SARS-CoV-2 in vitro and has favorable drug properties Ryan P. Bennett, Elena N. Postnikova, Brett P. Eaton, Yingyun Cai, Shuiqing Yu, Charles O. Smith, et al. (+6)
151 [GO] JCI Insight 2021―Nov―18 Atypical response to bacterial co-infection and persistent neutrophilic broncho-alveolar inflammation distinguish critical COVID-19 from influenza Seppe Cambier, Mieke Metzemaekers, Ana C. Carvalho, Amber Nooyens, Cato Jacobs, Lore Vanderbeke, et al. (+15)
152 [GO] Journal of Clinical Investigation 2021―Nov―17 A randomized controlled study of convalescent plasma for individuals hospitalized with COVID-19 pneumonia Katharine J. Bar, Pamela A. Shaw, Grace H. Choi, Nicole Aqui, Andrew Fesnak, Jasper B. Yang, et al. (+34)
153 [GO] Journal of Clinical Investigation 2021―Nov―14 Metabolic imbalance of T cells in COVID-19 is hallmarked by basigin and mitigated by dexamethasone Peter J. Siska, Sonja-Maria Decking, Nathalie Babl, Carina Matos, Christina Bruss, Katrin Singer, et al. (+40)
154 [GO] JCI Insight 2021―Nov―12 Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations Louisa Helms, Silvia Marchiano, Ian B. Stanaway, Tien-Ying Hsiang, Benjamin A. Juliar, Shally Saini, et al. (+16)
155 [GO] Journal of Clinical Investigation 2021―Nov―09 Family matters for coronavirus disease and vaccines David J. Bean, Manish Sagar
156 [GO] JCI Insight 2021―Nov―07 Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19 Suchitra Kamle, Bing Ma, Chuan Hua He, Bedia Akosman, Yang Zhou, Chang-Min Lee, et al. (+9)
157 [GO] JCI Insight 2021―Nov―03 SARS-CoV-2 infection mediates differential expression of human endogenous retroviruses and long interspersed nuclear elements Jez L. Marston, Matthew Greenig, Manvendra Singh, Matthew L. Bendall, Rodrigo R.R. Duarte, Cédric Feschotte, et al. (+2)
158 [GO] Journal of Clinical Investigation 2021―Oct―31 NK cell receptor and ligand composition influences the clearance of SARS-CoV-2 Wan-Chen Hsieh, En-Yu Lai, Yu-Ting Liu, Yi-Fu Wang, Yi-Shiuan Tzeng, Lu Cui, et al. (+22)
159 [GO] Journal of Clinical Investigation 2021―Oct―28 The intersection of COVID-19 and autoimmunity Jason S. Knight, Roberto Caricchio, Jean Laurent Casanova, Alexis J. Combes, Betty Diamond, Sharon E. Fox, et al. (+13)
160 [GO] Journal of Clinical Investigation 2021―Oct―21 Will GWAS eventually allow the identification of genomic biomarkers for COVID-19 severity and mortality? Vito Luigi Colona, Michela Bianocolella, Antonio Novelli, Giuseppe Novelli
161 [GO] JCI Insight 2021―Oct―19 Airway antibodies emerge according to COVID-19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination Alberto Cagigi, Meng Yu, Björn Österberg, Julia Svensson, Sara Falck-Jones, Sindhu Vangeti, et al. (+24)
162 [GO] Journal of Clinical Investigation 2021―Oct―08 Cross-protective immunity following coronavirus vaccination and coronavirus infection Tanushree Dangi, Nicole Palacio, Sarah Sanchez, Mincheol Park, Jake Class, Lavanya Visvabharathy, et al. (+4)
163 [GO] JCI Insight 2021―Oct―07 Human nasal wash RNA-seq reveals distinct cell-specific innate immune responses between influenza and SARS-CoV-2 Kevin M. Gao, Alan G. Derr, Zhiru Guo, Kerstin Nundel, Ann Marshak-Rothstein, Robert W. Finberg, Jennifer P. Wang
164 [GO] Journal of Clinical Investigation 2021―Oct―07 SARS-CoV-2 vaccine effectiveness in preventing confirmed infection in pregnant women Adeel A. Butt, Hiam Chemaitelly, Abdullatif Al Khal, Peter V Coyle, Huda Saleh, Anvar Kaleeckal, et al. (+4)
165 [GO] Journal of Clinical Investigation 2021―Oct―01 Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality Tomoko Nakanishi, Sara Pigazzini, Frauke Degenhardt, Mattia Cordioli, Guillaume Butler-Laporte, Douglas Maya-Miles, et al. (+41)
166 [GO] Journal of Clinical Investigation 2021―Sep―30 Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccine Ofer Beharier, Romina Plitman Mayo, Tal Raz, Kira Nahum Sacks, Letizia Schreiber, Yael Suissa-Cohen, et al. (+18)
167 [GO] Journal of Clinical Investigation 2021―Sep―14 Physician-scientists in the pandemic era: tidal wave or rising tide? Lorraine B. Ware
168 [GO] JCI Insight 2021―Sep―10 Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19 Alec A. Schmaier, Gabriel M. Pajares Hurtado, Zachary J. Manickas-Hill, Kelsey D. Sack, Siyu M. Chen, Victoria Bhambhani, et al. (+11)
169 [GO] JCI Insight 2021―Sep―10 More rapid, robust and sustainable antibody responses to mRNA COVID-19 vaccine in convalescent COVID-19 individuals Sabrina E. Racine-Brzostek, Jim K. Yee, Ashley Sukhu, Yuqing Qiu, Sophie Rand, Paul D. Barone, et al. (+10)
170 [GO] Journal of Clinical Investigation 2021―Sep―09 Seasonal coronavirus-specific B-cells with limited SARS-CoV-2 cross-reactivity dominate the IgG response in severe COVID-19 patients Muriel Aguilar-Bretones, Brenda M. Westerhuis, Matthijs P. Raadsen, Erwin de Bruin, Felicity D. Chandler, Nisreen M.A. Okba, et al. (+12)
171 [GO] Journal of Clinical Investigation 2021―Sep―02 A multicenter randomized open-label clinical trial for convalescent plasma in patients hospitalized with COVID-19 pneumonia Cristina Avendaño-Solá, Antonio Ramos-Martínez, Elena Muñez-Rubio, Belen Ruiz-Antorán, Rosa Malo de Molina, Ferran Torres, et al. (+31)
172 [GO] Journal of Clinical Investigation 2021―Aug―31 Convalescent plasma associates with reduced mortality and improved clinical trajectory in patients hospitalized with COVID-19 Shanna A. Arnold Egloff, Angela Junglen, Joseph S.A. Restivo, Marjorie Wongskhaluang, Casey Martin, Pratik Doshi, et al. (+6)
173 [GO] Journal of Clinical Investigation 2021―Aug―31 Results of the CAPSID randomized trial for high-dose convalescent plasma in severe COVID-19 patients Sixten Körper, Manfred Weiss, Daniel Zickler, Thomas Wiesmann, Kai Zacharowski, Victor M. Corman, et al. (+21)
174 [GO] JCI Insight 2021―Aug―31 Highly susceptible SARS-CoV-2 model in CAG promoter-driven hACE2 transgenic mice Masamitsu N. Asaka, Daichi Utsumi, Haruhiko Kamada, Satoshi Nagata, Yutaka Nakachi, Tomokazu Yamaguchi, et al. (+3)
175 [GO] Journal of Clinical Investigation 2021―Aug―31 Rapid measurement of SARS-CoV-2 spike T cells in whole blood from vaccinated and naturally infected individuals Anthony T. Tan, Joey M.E. Lim, Nina Le Bert, Kamini Kunasegaran, Adeline Chia, Martin D.C. Qui, et al. (+12)
176 [GO] JCI Insight 2021―Aug―27 A dynamic mucin mRNA signature associates with COVID-19 disease presentation and severity Annemieke Smet, Tom Breugelmans, Johan Michiels, Kevin Lamote, Wout Arras, Joris G. De Man, et al. (+16)
177 [GO] Journal of Clinical Investigation 2021―Aug―27 Attenuated activation of pulmonary immune cells in mRNA-1273 vaccinated hamsters after SARS-CoV-2 infection Michelle Meyer, Yuan Wang, Darin Edwards, Gregory R. Smith, Aliza B. Rubenstein, Palaniappan Ramanathan, et al. (+22)
178 [GO] Journal of Clinical Investigation 2021―Aug―19 Intravenous bamlanivimab use associates with reduced hospitalization in high-risk patients with mild to moderate COVID-19 Ravindra Ganesh, Colin F. Pawlowski, John C. O'Horo, Lori L. Arndt, Richard F. Arndt, Sarah Bell, et al. (+14)
179 [GO] Journal of Clinical Investigation 2021―Aug―19 Association of in-hospital use of ACE-I/ARB and COVID-19 outcomes in African American population Shilong Li, Rangaprasad Sarangarajan, Tomi Jun, Yu-Han Kao, Zichen Wang, Ke Hao, et al. (+7)
180 [GO] JCI Insight 2021―Aug―17 Self-sustaining interleukin-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19 Rainer Kaiser, Alexander Leunig, Kami Pekayvaz, Oliver Popp, Markus Joppich, Vivien Polewka, et al. (+24)
181 [GO] Journal of Clinical Investigation 2021―Aug―17 Group IIA secreted phospholipase A2 is associated with the pathobiology leading to COVID-19 mortality Justin M. Snider, Jeehyun Karen You, Xia Wang, Ashley J. Snider, Brian Hallmark, Manja M. Zec, et al. (+18)
182 [GO] JCI Insight 2021―Aug―17 Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long-COVID John P. Haran, Evan Bradley, Abigail L. Zeamer, Lindsey Cincotta, Marie-Claire Salive, Protiva Dutta, et al. (+7)
183 [GO] Journal of Clinical Investigation 2021―Aug―10 Dominance of alpha and Iota variants in SARS-CoV-2 vaccine breakthrough infections in New York City Ralf Duerr, Dacia Dimartino, Christian Marier, Paul Zappile, Guiqing Wang, Jennifer Lighter, et al. (+3)
184 [GO] JCI Insight 2021―Aug―10 SARS-CoV-2-associated ssRNAs activate inflammation and immunity via TLR7/8 Valentina Salvi, Hoang Oanh Nguyen, Francesca Sozio, Tiziana Schioppa, Carolina Gaudenzi, Mattia Laffranchi, et al. (+11)
185 [GO] JCI Insight 2021―Aug―06 Ex vitro SARS-CoV-2 infection of human lung reveals heterogeneous host defense and therapeutic responses Matthew A. Schaller, Yamini Sharma, Zadia Dupee, Duy T. Nguyen, Juan M. Urueña, Ryan A. Smolchek, et al. (+7)
186 [GO] JCI Insight 2021―Jul―27 COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction Kimberly A. Queisser, Rebecca A. Mellema, Elizabeth A. Middleton, Irina Portier, Bhanu Kanth Manne, Frederik Denorme, et al. (+4)
187 [GO] JCI Insight 2021―Jul―21 L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus Yuji Kondo, Jason L. Larabee, Liang Gao, Huiping Shi, Bojing Shao, Christopher M. Hoover, et al. (+15)
188 [GO] JCI Insight 2021―Jul―20 Nucleocapsid-specific and PD-L1+CXCR3+ CD8 polyfunctional T-cell abundances are associated with survival of critical SARS-CoV2-infected patients Lucille Adam, Pierre Rosenbaum, Paul Quentric, Christophe Parizot, Olivia Bonduelle, Noëlline Guillou, et al. (+8)
189 [GO] Journal of Clinical Investigation 2021―Jul―14 Distinctive features of severe SARS-CoV-2 pneumonia G.R. Scott Budinger, Alexander V. Misharin, Karen M. Ridge, Benjamin D. Singer, Richard G. Wunderink
190 [GO] JCI Insight 2021―Jul―12 Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assay Ester Lopez, Ebene R. Haycroft, Amy Adair, Francesca L. Mordant, Matthew T. O'Neill, Phillip Pymm, et al. (+15)
191 [GO] JCI Insight 2021―Jul―12 HIV infection drives interferon signalling within intestinal SARS-CoV-2 target cells Rabiah Fardoos, Osaretin E. Asowata, Nicholas Herbert, Sarah K. Nyquist, Yenzekile Zungu, Alveera Singh, et al. (+14)
192 [GO] JCI Insight 2021―Jul―09 SARS-CoV-2 infection of the pancreas promotes thrombo-fibrosis and is associated with new-onset diabetes Mirza Muhammad Fahd Qadir, Manika Bhondeley, Wandy Beatty, Dina D. Gaupp, Lara A. Doyle-Meyers, Tracy Fischer, et al. (+9)
193 [GO] JCI Insight 2021―Jul―08 Health care worker sero-monitoring reveals complex relationships between common coronavirus antibodies and COVID-19 symptom duration Sigrid Gouma, Madison E. Weirick, Marcus J. Bolton, Claudia P. Arevalo, Eileen C. Goodwin, Elizabeth M. Anderson, et al. (+12)
194 [GO] JCI Insight 2021―Jul―06 Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents Carolina Garrido, Jillian H. Hurst, Cynthia G. Lorang, Jhoanna N. Aquino, Javier Rodriguez, Trevor S. Pfeiffer, et al. (+13)
195 [GO] Journal of Clinical Investigation 2021―Jun―30 SARS-CoV-2 viremia is associated with distinct proteomic pathways and predicts COVID-19 outcomes Yijia Li, Alexis M. Schneider, Arnav Mehta, Moshe Sade-Feldman, Kyle R. Kays, Matteo Gentili, et al. (+24)
196 [GO] JCI Insight 2021―Jun―29 IL-13 is a driver of COVID-19 severity Alexandra N. Donlan, Tara E. Sutherland, Chelsea Marie, Saskia Preissner, Benjamin T. Bradley, Rebecca M. Carpenter, et al. (+21)
197 [GO] JCI Insight 2021―Jun―24 Autoantibodies stabilize neutrophil extracellular traps in COVID-19 Yu Zuo, Srilakshmi Yalavarthi, Sherwin A. Navaz, Claire K. Hoy, Alyssa Harbaugh, Kelsey Gockman, et al. (+5)
198 [GO] Journal of Clinical Investigation 2021―Jun―24 Association of rare predicted loss-of-function variants of influenza-related type I IFN genes with critical COVID-19 pneumonia Qian Zhang, Aurélie Cobat, Paul Bastard, Luigi D. Notarangelo, Helen C. Su, Laurent Abel, Jean-Laurent Casanova
199 [GO] Journal of Clinical Investigation 2021―Jun―22 Association of rare predicted loss-of-function variants of influenza-related type I IFN genes with critical COVID-19 pneumonia. Reply Gundula Povysil, Guillaume Butler-Laporte, Ali G. Gharavi, J. Brent Richards, David B. Goldstein, Krzysztof Kiryluk
200 [GO] JCI Insight 2021―Jun―18 COVID-19 and RA share SPP1 myeloid pathway that drives PD-L1pos neutrophils and CD14pos monocytes Lucy MacDonald, Stefano Alivernini, Barbara Tolusso, Aziza Elmesmari, Domenico Somma, Simone Perniola, et al. (+20)
201 [GO] Journal of Clinical Investigation 2021―Jun―18 Interpreting and addressing suboptimal immune responses after COVID-19 vaccination in solid organ transplant recipients Peter G. Stock, Timothy J. Henrich, Dorry L. Segev, William A. Werbel
202 [GO] JCI Insight 2021―Jun―18 Duration of post-COVID-19 symptoms are associated with sustained SARS-CoV-2 specific immune responses Jacob K. Files, Sanghita Sarkar, Timothy R Fram., Sushma Boppana, Sarah Sterrett, Kai Qin, et al. (+6)
203 [GO] JCI Insight 2021―Jun―10 Immuno-fibrotic drivers of impaired lung function in post-acute sequelae of SARS-CoV-2 Hyung J. Chun, Elias Coutavas, Alexander B. Pine, Alfred I. Lee, Vanessa L. Yu, Marcus K. Shallow, et al. (+6)
204 [GO] Journal of Clinical Investigation 2021―Jun―08 Impaired humoral and cellular immunity after SARS-CoV2 BNT162b2 (Tozinameran) prime-boost vaccination in kidney transplant recipients Arne Sattler, Eva Schrezenmeier, Ulrike A. Weber, Alexander Potekhin, Friederike Bachmann, Henriette Straub-Hohenbleicher, et al. (+19)
205 [GO] JCI Insight 2021―Jun―03 Epitope-specific antibody responses differentiate COVID-19 outcome and variants of concern Courtney Voss, Sally Esmail, Xuguang Liu, Michael J. Knauer, Suzanne Ackloo, Tomonori Kaneko, et al. (+20)
206 [GO] Journal of Clinical Investigation 2021―Jun―01 Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D Jian Zheng, David Meyerholz, Lok-Yin Roy Wong, Michael Gelb, Makoto Murakami, Stanley Perlman
207 [GO] JCI Insight 2021―Jun―01 Cardiovascular complications of COVID-19 Farnaz Farshidfar, Navid Koleini, Hossein Ardehali
208 [GO] Journal of Clinical Investigation 2021―Jun―01 Mild COVID-19 despite autoantibodies to type I IFNs in Autoimmune-Polyendocrine-Syndrome Type 1 (APS-1) Christian Meisel, Bengisu Akbil, Tim Meyer, Erwin Lankes, Victor M. Corman, Olga Staudacher, et al. (+8)
209 [GO] Journal of Clinical Investigation 2021―Jun―01 Do monogenic inborn errors of immunity cause susceptibility to severe COVID-19? Chris Cotsapas, Janna Saarela, Jocelyn R. Farmer, Vinod Scaria, Roshini S. Abraham
210 [GO] Journal of Clinical Investigation 2021―May―27 Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19 Gundula Povysil, Guillaume Butler-Laporte, Ning Shang, Chen Wang, Atlas Khan, Manal Alaamery, et al. (+46)
211 [GO] JCI Insight 2021―May―23 The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2-infected patients by sex and age Paula P. Freire, Alexandre H.C. Marques, Gabriela C. Baiocchi, Lena F. Schimke, Dennyson L.M. Fonseca, Ranieri C. Salgado, et al. (+17)
212 [GO] Journal of Clinical Investigation 2021―May―21 Mounting evidence for immunizing previously infected subjects with a single dose of SARS-CoV-2 vaccine Gonzalo Perez Marc, Damian Alvarez-Paggi, Fernando P. Polack
213 [GO] Journal of Clinical Investigation 2021―May―20 Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccine Ofer Beharier, Romina Plitman Mayo, Tal Raz, Kira Nahum Sacks, Letizia Schreiber, Yael Suissa-Cohen, et al. (+18)
214 [GO] Journal of Clinical Investigation 2021―May―18 Nasal ciliated cells are primary targets for SARS-CoV-2 replication in early stage of COVID-19 Ji Hoon Ahn, JungMo Kim, Seon Pyo Hong, Sung Yong Choi, Myung Jin Yang, Young Seok Ju, et al. (+8)
215 [GO] Journal of Clinical Investigation 2021―May―11 A randomized double-blind controlled trial of convalescent plasma in adults with severe COVID-19 Max R. O'Donnell, Beatriz Grinsztejn, Matthew J. Cummings, Jessica E. Justman, Matthew R. Lamb, Christina M. Eckhardt, et al. (+36)
216 [GO] JCI Insight 2021―May―11 Mice with induced pulmonary morbidities display severe lung inflammation and mortality following exposure to SARS-CoV-2 Reut Falach, Liat Bar-On, Shlomi Lazar, Tamar Kadar, Ohad Mazor, Moshe Aftalion, et al. (+24)
217 [GO] Journal of Clinical Investigation 2021―May―11 What should define a SARS-CoV-2 “breakthrough” infection? John S. Schieffelin, Elizabeth B. Norton, Jay K. Kolls
218 [GO] JCI Insight 2021―May―09 A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients Samantha M. Morrissey, Anne E. Geller, Xiaoling Hu, David Tieri, Chuanlin Ding, Christopher K. Klaes, et al. (+19)
219 [GO] Journal of Clinical Investigation 2021―May―06 One dose of SARS-CoV-2 vaccine exponentially increases antibodies in recovered individuals with symptomatic COVID-19 Riccardo Levi, Elena Azzolini, Chiara Pozzi, Leonardo Ubaldi, Michele Lagioia, Alberto Mantovani, Maria Rescigno
220 [GO] Journal of Clinical Investigation 2021―May―04 Relationship of SARS-CoV-2-specific CD4 response to COVID-19 severity and impact of HIV-1 and Tuberculosis co-infection Catherine Riou, Elsa Du Bruyn, Cari Stek, Remy Daroowala, Rene T. Goliath, Fatima Abrahams, et al. (+8)
221 [GO] Journal of Clinical Investigation 2021―May―04 Is complement the culprit behind COVID-19 vaccine-related adverse reactions? Dimitrios C. Mastellos, Panagiotis Skendros, John D. Lambris
222 [GO] Journal of Clinical Investigation 2021―May―03 First-dose mRNA vaccination is sufficient to reactivate immunological memory to SARS-CoV-2 in recovered COVID-19 subjects Alessio Mazzoni, Nicoletta Di Lauria, Laura Maggi, Lorenzo Salvati, Anna Vanni, Manuela Capone, et al. (+16)
223 [GO] JCI Insight 2021―Apr―28 Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques Yongjun Sui, Jianping Li, Roushu Zhang, Sunaina Kiran Prabhu, Hanne Andersen Elyard, David Venzon, et al. (+19)
224 [GO] JCI Insight 2021―Apr―22 Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirus Ami Patel, Emma L. Reuschel, Ziyang Xu, Faraz I. Zaidi, Kevin Y. Kim, Dana P. Scott, et al. (+17)
225 [GO] Journal of Clinical Investigation 2021―Apr―12 SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children (MIS-C) Theodore Kouo, Worarat Chaisawangwong
226 [GO] Journal of Clinical Investigation 2021―Apr―12 Structure-based phylogeny identifies Avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice Young Joo Sun, Gabriel Velez, Dylan E. Parsons, Kun Li, Miguel E. Ortiz, Shaunik Sharma, et al. (+3)
227 [GO] Journal of Clinical Investigation 2021―Apr―08 Functional characterization of CD4+ T-cell receptors cross-reactive for SARS-CoV-2 and endemic coronaviruses Arbor G. Dykema, Boyang Zhang, Bezawit A. Woldemeskel, Caroline C. Garliss, Laurene S. Cheung, Dilshad Choudhury, et al. (+22)
228 [GO] JCI Insight 2021―Apr―06 Natural mucosal barriers and COVID-19 in children Carl A. Pierce, Sharlene Sy, Benjamin Galen, Doctor Y. Goldstein, Erika P. Orner, Marla J. Keller, et al. (+2)
229 [GO] Journal of Clinical Investigation 2021―Apr―06 SARS-CoV-2 mRNA vaccines induce broad CD4+ T cell responses that recognize SARS-CoV-2 variants and HCoV-NL63 Bezawit A. Woldemeskel, Caroline C. Garliss, Joel N. Blankson
230 [GO] JCI Insight 2021―Apr―06 SARS-CoV-2 vaccines: a triumph of science and collaboration Jonathan L. Golob, Njira Lugogo, Adam S. Lauring, Anna S. Lok
231 [GO] JCI Insight 2021―Mar―23 Patterns and persistence of SARS-CoV-2 IgG antibodies in Chicago to monitor COVID-19 exposure Alexis R. Demonbreun, Thomas W. McDade, Lorenzo L. Pesce, Lauren A. Vaught, Nina L. Reiser, Elena Bogdanovic, et al. (+11)
232 [GO] JCI Insight 2021―Mar―21 Genomic diversity of SARS-CoV-2 during early introduction into the Baltimore-Washington metropolitan area Peter M. Thielen, Shirlee Wohl, Thomas Mehoke, Srividya Ramakrishnan, Melanie Kirsche, Oluwaseun Falade-Nwulia, et al. (+16)
233 [GO] Journal of Clinical Investigation 2021―Mar―16 A sobering addition to the literature on COVID-19 and the brain Amit Mahajan, Graeme F. Mason
234 [GO] JCI Insight 2021―Mar―15 A majority of uninfected adults show pre-existing antibody reactivity against SARS-CoV-2 Abdelilah Majdoubi, Christina Michalski, Sarah E. O’Connell, Sarah Dada, Sandeep R. Narpala, Jean P. Gelinas, et al. (+17)
235 [GO] JCI Insight 2021―Mar―02 Cell-free DNA maps COVID-19 tissue injury and risk of death, and can cause tissue injury Temesgen E. Andargie, Naoko Tsuji, Fayaz Seifuddin, Moon Kyoo Jang, Peter S.T. Yuen, Hyesik Kong, et al. (+9)
236 [GO] JCI Insight 2021―Feb―27 Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-2 Krystle K.Q. Yu, Stephanie Fischinger, Malisa T. Smith, Caroline Atyeo, Deniz Cizmeci, Caitlin R. Wolf, et al. (+15)
237 [GO] Journal of Clinical Investigation 2021―Feb―26 Identification of SARS-CoV-2-specific immune alterations in acutely ill patients Rose-Marie Rébillard, Marc Charabati, Camille Grasmuck, Abdelali Filali-Mouhim, Olivier Tastet, Nathalie Brassard, et al. (+32)
238 [GO] Journal of Clinical Investigation 2021―Feb―25 Long-term micro-structure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations Yuanyuan Qin, Jinfeng Wu, Tao Chen, Jia Li, Guiling Zhang, Di Wu, et al. (+8)
239 [GO] Journal of Clinical Investigation 2021―Feb―23 SARS-Cov2 variants and convalescent plasma: reality, fallacies, and opportunities Arturo Casadevall, Jeffrey Henderson, Michael Joyner, Liise-anne Pirofski
240 [GO] Journal of Clinical Investigation 2021―Feb―11 Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality William R. Morgenlander, Stephanie N. Henson, Daniel R. Monaco, Athena Chen, Kirsten Littlefield, Evan M. Bloch, et al. (+23)
241 [GO] Journal of Clinical Investigation 2021―Feb―11 Durable SARS-CoV-2 B cell immunity after mild or severe disease Clinton O. Ogega, Nicole E. Skinner, Paul W. Blair, Han-Sol Park, Kirsten Littlefield, Abhinaya Ganesan, et al. (+10)
242 [GO] JCI Insight 2021―Feb―11 Clinical and laboratory evaluation of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma Michele L. Donato, Steven Park, Melissa Baker, Robert Korngold, Alison Morawski, Xue Geng, et al. (+42)
243 [GO] Journal of Clinical Investigation 2021―Feb―09 Sensitive tracking of circulating viral RNA through all stages of SARS-CoV-2 infection Zhen Huang, Bo Ning, He S. Yang, Brady M. Youngquist, Alex Niu, Christopher J. Lyon, et al. (+19)
244 [GO] JCI Insight 2021―Feb―02 Dromedary camels as a natural source of neutralizing nanobodies against SARS-CoV-2 Lotfi Chouchane, Jean-Charles Grivel, Elmoubasher Farag, Igor Pavlovski, Selma Maacha, Abbirami Sathappan, et al. (+11)
245 [GO] Journal of Clinical Investigation 2021―Feb―01 The COVID-19 immune landscape is dynamically and reversibly correlated with disease severity Hamid Bolouri, Cate Speake, David Skibinski, S. Alice Long, Anne M. Hocking, Daniel J. Campbell, et al. (+3)
246 [GO] Journal of Clinical Investigation 2021―Jan―26 Similarities and differences between the immunopathogenesis of COVID-19-related pediatric inflammatory multisystem syndrome and Kawasaki disease Ana Esteve-Sole, Jordi Anton, Rosa Maria Pino-Ramírez, Judith Sanchez-Manubens, Victoria Fumadó, Clàudia Fortuny, et al. (+17)
247 [GO] JCI Insight 2021―Jan―26 Distinct antibody repertoires against endemic human coronaviruses in children and adults Taushif Khan, Mahbuba Rahman, Fatima Al Ali, Susie S.Y. Huang, Manar Ata, Qian Zhang, et al. (+19)
248 [GO] Journal of Clinical Investigation 2021―Jan―26 Severe SARS-CoV-2 placenta infection can impact neonatal outcome in the absence of vertical transmission Fulvia Milena Cribié, Roberta Erra, Lorenza Pugni, Carlota Rubio-Perez, Lidia Alonso, Sara Simonetti, et al. (+16)
249 [GO] Journal of Clinical Investigation 2021―Jan―25 Functional monocytic myeloid-derived suppressor cells increase in blood but not airways and predict COVID-19 severity Sara Falck-Jones, Sindhu Vangeti, Meng Yu, Ryan Falck-Jones, Alberto Cagigi, Isabella Badolati, et al. (+16)
250 [GO] JCI Insight 2021―Jan―21 Rectifying COVID-19 disparities with treatment and vaccination John M. Carethers
251 [GO] JCI Insight 2021―Jan―21 Effective virus-neutralizing activities in antisera from the first wave of severe COVID-19 survivors Yang Han, Peipei Liu, Yang Qiu, Jie Zhou, Ying Liu, Xujuan Hu, et al. (+13)
252 [GO] JCI Insight 2021―Jan―21 Treatment of Severe COVID-19 with Convalescent Plasma in Bronx, NYC Hyun ah Yoon, Rachel Bartash, Inessa Gendlina, Johanna Rivera, Antonio Nakouzi, Robert H. Bortz III, et al. (+49)
253 [GO] JCI Insight 2021―Jan―14 Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19 Davide Scozzi, Marlene Cano, Lina Ma, Dequan Zhou, Ji Hong Zhu, Jane A. O’Halloran, et al. (+15)
254 [GO] Journal of Clinical Investigation 2021―Jan―14 COVID-19 vaccine testing in pregnant females is necessary Sabra L. Klein, Patrick S. Creisher, Irina Burd
255 [GO] Journal of Clinical Investigation 2021―Jan―11 SARS-CoV-2-specific CD8+ T cell responses in convalescent COVID-19 individuals Hassen Kared, Andrew D. Redd, Evan M. Bloch, Tania S. Bonny, Hermi R. Sumatoh, Faris Kairi, et al. (+16)
256 [GO] JCI Insight 2021―Jan―10 Dissecting strategies to tune the therapeutic potential of SARS-CoV-2-specific monoclonal antibody CR3022 Caroline Atyeo, Matthew D. Slein, Stephanie Fischinger, John Burke, Alexandra Schäfer, Sarah R. Leist, et al. (+20)
257 [GO] Journal of Clinical Investigation 2020―Dec―15 Clinical, laboratory, and temporal predictors of neutralizing antibodies to SARS-CoV-2 among COVID-19 convalescent plasma donor candidates Jim Boonyaratanakornkit, Chihiro Morishima, Stacy Selke, Danniel Zamora, Sarah A. McGuffin, Adrienne E. Shapiro, et al. (+19)
258 [GO] Journal of Clinical Investigation 2020―Dec―11 BCG vaccination in healthcare providers and the protection against COVID-19 Mihai G. Netea, Jos W.M. van der Meer, Reinout van Crevel
259 [GO] JCI Insight 2020―Dec―07 Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2 induced systemic toxicity Shen Li, Feiyang Ma, Tomohiro Yokota, Gustavo Garcia Jr., Amelia Palermo, Yijie Wang, et al. (+18)
260 [GO] JCI Insight 2020―Nov―24 An immune-based biomarker signature is associated with mortality in COVID-19 patients Michael S. Abers, Ottavia M. Delmonte, Emily E. Ricotta, Jonathan Fintzi, Danielle Fink, Adriana A. de Jesus, et al. (+40)
261 [GO] Journal of Clinical Investigation 2020―Nov―20 Does common cold coronavirus infection protect against severe SARS-CoV2 disease? David K. Meyerholz, Stanley Perlman
262 [GO] Journal of Clinical Investigation 2020―Nov―20 SARS-CoV-2 B cell receptor signatures in risk populations Andrew I. Flyak
263 [GO] Journal of Clinical Investigation 2020―Nov―19 BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of healthcare workers Magali Noval Rivas, Joseph E. Ebinger, Min Wu, Nancy Sun, Jonathan Braun, Kimia Sobhani, et al. (+3)
264 [GO] Journal of Clinical Investigation 2020―Nov―12 Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium Bryce A. Schuler, A. Christian Habermann, Erin J. Plosa, Chase J. Taylor, Christopher Jetter, Nicholas M. Negretti, et al. (+13)
265 [GO] Journal of Clinical Investigation 2020―Nov―10 Emergency seed funding for COVID-19 research: lessons from Johns Hopkins University Julie Messersmith, Chasmine Stoddart-Osumah, Marc Lennon, Denis Wirtz
266 [GO] Journal of Clinical Investigation 2020―Nov―02 Corticosteroid treatment in severe COVID-19 patients with acute respiratory distress syndrome Jiao Liu, Sheng Zhang, Xuan Dong, Zhongyi Li, Qianghong Xu, Huibin Feng, et al. (+14)
267 [GO] Journal of Clinical Investigation 2020―Oct―29 Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection Jacob K. Files, Sushma Boppana, Mildred D. Perez, Sanghita Sarkar, Kelsey E. Lowman, Kai Qin, et al. (+9)
268 [GO] Journal of Clinical Investigation 2020―Oct―27 Inflammatory syndromes associated with SARS-CoV-2 infection: dysregulation of the immune response across the age spectrum Jill E. Weatherhead, Eva H. Clark, Tiphanie P. Vogel, Robert L. Atmar, Prathit A. Kulkarni
269 [GO] Journal of Clinical Investigation 2020―Oct―26 Prolonged adaptive immune activation in COVID-19: implications for maintenance of long-term immunity? Philip A. Mudd, Kenneth E. Remy
270 [GO] JCI Insight 2020―Oct―22 Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models Kyle Rosenke, Michael A. Jarvis, Friederike Feldmann, Benjamin Schwarz, Atsushi Okumura, Jamie Lovaglio, et al. (+17)
271 [GO] Journal of Clinical Investigation 2020―Oct―21 Age-related susceptibility to Coronavirus infections: role of impaired and dysregulated host immunity Rudragouda Channappanavar, Stanley Perlman
272 [GO] Journal of Clinical Investigation 2020―Oct―16 SARS-CoV-2 specific antibody rearrangements in pre-pandemic immune repertoires of risk cohorts and COVID-19 patients Lisa Paschold, Donjete Simnica, Edith Willscher, Maria J.G.T. Vehreschild, Jochen Dutzmann, Daniel G. Sedding, et al. (+2)
273 [GO] Journal of Clinical Investigation 2020―Oct―15 What are protective antibody responses to pandemic SARS-CoV-2? Jeffrey P. Henderson
274 [GO] JCI Insight 2020―Oct―09 Neutralizing antibody against SARS-CoV-2 spike in COVID-19 patients, health care workers and convalescent plasma donors Cong Zeng, John P. Evans, Rebecca Pearson, Panke Qu, Yi-Min Zheng, Richard T. Robinson, et al. (+8)
275 [GO] Journal of Clinical Investigation 2020―Oct―06 COVID-19 and myeloid cells: complex interplay correlates with lung severity Franco R. D'Alessio, Nicola M. Heller
276 [GO] Journal of Clinical Investigation 2020―Sep―30 Recent endemic coronavirus infection is associated with less severe COVID-19 Manish Sagar, Katherine Reifler, Michael Rossi, Nancy S. Miller, Pranay Sinha, Laura White, Joseph P. Mizgerd
277 [GO] Journal of Clinical Investigation 2020―Sep―29 COVID-19 survival associates with the immunoglobulin response to the SARS-CoV-2 spike Receptor Binding Domain Massimiliano Secchi, Elena Bazzigaluppi, Cristina Brigatti, Ilaria Marzinotto, Cristina Tresoldi, Patrizia Rovere-Querini, et al. (+7)
278 [GO] Journal of Clinical Investigation 2020―Sep―25 Corticosteroids, COVID-19 pneumonia and acute respiratory distress syndrome Michael A. Matthay, Katherine D. Wick
279 [GO] Journal of Clinical Investigation 2020―Sep―25 Are T cells helpful for COVID-19: the relationship between response and risk Diane E. Griffin
280 [GO] Journal of Clinical Investigation 2020―Sep―23 Healthy donor T-cell responses to common cold coronaviruses and SARS-CoV-2 Bezawit A. Woldemeskel, Abena K. Kwaa, Caroline C. Garliss, Oliver Laeyendecker, Stuart C. Ray, Joel N. Blankson
281 [GO] JCI Insight 2020―Sep―16 High levels of SARS-CoV-2 specific T-cells with restricted functionality in severe course of COVID-19 David Schub, Verena Klemis, Sophie Schneitler, Janine Mihm, Philipp M. Lepper, Heinrike Wilkens, et al. (+7)
282 [GO] Journal of Clinical Investigation 2020―Sep―15 Drugs of unproven benefit for COVID-19: a pharma perspective on ethical allocation of available therapies Arthur L. Caplan, Joanne Waldstreicher, Karla Childers, Aran Maree
283 [GO] Journal of Clinical Investigation 2020―Sep―14 Complement and coagulation: key triggers of COVID-19-induced multiorgan pathology Berhane Ghebrehiwet, Ellinor I. Peerschke
284 [GO] Journal of Clinical Investigation 2020―Sep―09 Caring for patients in a new pandemic: the necessity and challenges of observational research David L. Thomas
285 [GO] Journal of Clinical Investigation 2020―Sep―08 Favorable outcomes of COVID-19 in recipients of hematopoietic cell transplantation Gunjan L. Shah, Susan DeWolf, Yeon Joo Lee, Roni Tamari, Parastoo B. Dahi, Jessica A. Lavery, et al. (+22)
286 [GO] Journal of Clinical Investigation 2020―Sep―01 Immune pathogenesis of COVID-19-related Multisystem Inflammatory Syndrome in Children (MIS-C) Anne H. Rowley, Stanford T. Shulman, Moshe Arditi
287 [GO] JCI Insight 2020―Sep―01 A simple protein-based surrogate neutralization assay for SARS-CoV-2 Kento T. Abe, Zhijie Li, Reuben Samson, Payman Samavarchi-Tehrani, Emelissa J. Valcourt, Heidi Wood, et al. (+17)
288 [GO] Journal of Clinical Investigation 2020―Aug―25 Peripheral CD4+ T cell subsets and antibody response in COVID-19 convalescent individuals Fang Gong, Yaping Dai, Ting Zheng, Liang Cheng, Dan Zhao, Hao Wang, et al. (+5)
289 [GO] JCI Insight 2020―Aug―25 Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease Joseph W. Golden, Curtis R. Cline, Xiankun Zeng, Aura R. Garrison, Brian D. Carey, Eric M. Mucker, et al. (+11)
290 [GO] Journal of Clinical Investigation 2020―Aug―24 SARS-CoV-2 specific T-cell responses and correlations with COVID-19 patient predisposition Arne Sattler, Stefan Angermair, Helena Stockmann, Katrin Moira Heim, Dmytro Khadzhynov, Sascha Treskatsch, et al. (+3)
291 [GO] Journal of Clinical Investigation 2020―Aug―18 Baricitinib restrains the immune dysregulation in severe COVID-19 patients Vincenzo Bronte, Stefano Ugel, Elisa Tinazzi, Antonio Vella, Francesco De Sanctis, Stefania Canè, et al. (+24)
292 [GO] JCI Insight 2020―Aug―14 Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications on COVID-19 immunity Kathleen M. McAndrews, Dara P. Dowlatshahi, Jianli Dai, Lisa M. Becker, Janine Hensel, Laura M. Snowden, et al. (+13)
293 [GO] Journal of Clinical Investigation 2020―Aug―12 COVID-19 severity associates with pulmonary redistribution of CD1c+ DC and inflammatory transitional and nonclassical monocytes Ildefonso Sánchez-Cerrillo, Pedro Landete, Beatriz Aldave, Santiago Sánchez-Alonso, Ana Sánchez-Azofra, Ana Marcos-Jiménez, et al. (+18)
294 [GO] Journal of Clinical Investigation 2020―Aug―07 Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population Sabra L. Klein, Andrew Pekosz, Han-Sol Park, Rebecca L. Ursin, Janna R. Shapiro, Sarah E. Benner, et al. (+17)
295 [GO] Journal of Clinical Investigation 2020―Aug―06 Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis Panagiotis Skendros, Alexandros Mitsios, Akrivi Chrysanthopoulou, Dimitrios C. Mastellos, Simeon Metallidis, Petros Rafailidis, et al. (+11)
296 [GO] Journal of Clinical Investigation 2020―Aug―03 Toward better preparedness for the next pandemic Lauren I. Shapiro, Grace R. Kajita, Julia H. Arnsten, Yaron Tomer
297 [GO] Journal of Clinical Investigation 2020―Jul―30 Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2 Caroline Diorio, Sarah E. Henrickson, Laura A. Vella, Kevin O. McNerney, Julie M. Chase, Chakkapong Burudpakdee, et al. (+31)
298 [GO] Journal of Clinical Investigation 2020―Jul―30 COVID-19, racism, and the pursuit of health care and research worthy of trust Lisa A. Cooper, Deidra C. Crews
299 [GO] JCI Insight 2020―Jul―24 Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis Jennifer G. Wilson, Laura J. Simpson, Anne-Maud Ferreira, Arjun Rustagi, Jonasel A. Roque, Adijat Asuni, et al. (+9)
300 [GO] Journal of Clinical Investigation 2020―Jul―23 Distinct clinical and immunological features of SARS-COV-2-induced multisystem inflammatory syndrome in children Pui Y. Lee, Megan Day-Lewis, Lauren A. Henderson, Kevin Friedman, Jeffrey Lo, Jordan E. Roberts, et al. (+23)
301 [GO] Journal of Clinical Investigation 2020―Jul―21 Prioritizing clinical research studies during the COVID-19 pandemic: lessons from New York City Roy M. Gulick, Magdalena E. Sobieszczyk, Donald W. Landry, Anthony N. Hollenberg
302 [GO] JCI Insight 2020―Jul―20 Severe immunosuppression and not a cytokine storm characterize COVID-19 infections Kenneth E. Remy, Monty Mazer, David A. Striker, Ali H. Ellebedy, Andrew H. Walton, Jacqueline Unsinger, et al. (+15)
303 [GO] Journal of Clinical Investigation 2020―Jul―07 Kinetics of viral load and antibody response in relation to COVID-19 severity Yanqun Wang, Lu Zhang, Ling Sang, Feng Ye, Shicong Ruan, Bei Zhong, et al. (+38)
304 [GO] Journal of Clinical Investigation 2020―Jul―07 SARS-CoV-2 viral load and antibody responses: the case for convalescent plasma therapy Arturo Casadevall, Michael J. Joyner, Liise-anne Pirofski
305 [GO] Journal of Clinical Investigation 2020―Jun―23 SARS-CoV-2 infection of the placenta Hillary Hosier, Shelli F. Farhadian, Raffaella A. Morotti, Uma Deshmukh, Alice Lu-Culligan, Katherine H. Campbell, et al. (+30)
306 [GO] JCI Insight 2020―Jun―19 COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status Tiffany Thomas, Davide Stefanoni, Julie A. Reisz, Travis Nemkov, Lorenzo Bertolone, Richard O. Francis, et al. (+6)
307 [GO] JCI Insight 2020―Jun―18 The complement system in COVID-19: friend and foe? Anuja Java, Anthony J. Apicelli, M. Kathryn Liszewski, Ariella Coler-Reilly, John P. Atkinson, Alfred H.J. Kim, Hrishikesh S. Kulkarni
308 [GO] JCI Insight 2020―Jun―16 IL-6 combined with CD8+ T cell count early predict in-hospital mortality for patients with COVID-19 Miao Luo, Jing Liu, Weiling Jiang, Shuang Yue, Huiguo Liu, Shuang Wei
309 [GO] JCI Insight 2020―Jun―12 New (re)Purpose for an old drug: purinergic receptor blockade may extinguish the COVID-19 thrombo-inflammatory firestorm Yogendra Kanthi, Jason S. Knight, Yu Zuo, David J. Pinsky
310 [GO] Journal of Clinical Investigation 2020―Jun―11 Early safety indicators of COVID-19 convalescent plasma in 5,000 patients Michael J. Joyner, R. Scott Wright, DeLisa Fairweather, Jonathon W. Senefeld, Katelyn A. Bruno, Stephen A. Klassen, et al. (+30)
311 [GO] JCI Insight 2020―Jun―05 Longitudinal COVID-19 profiling associates IL-1Ra and IL-10 with disease severity and RANTES with mild disease Yan Zhao, Ling Qin, Ping Zhang, Kang Li, Lianchun Liang, Jianping Sun, et al. (+16)
312 [GO] Journal of Clinical Investigation 2020―May―28 Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent Alessio Mazzoni, Lorenzo Salvati, Laura Maggi, Manuela Capone, Anna Vanni, Michele Spinicci, et al. (+23)
313 [GO] Journal of Clinical Investigation 2020―May―28 New York City COVID-19 resident physician exposure during exponential phase of pandemic Mark P. Breazzano, Junchao Shen, Aliaa H. Abdelhakim, Lora Dagi Glass, Jason Horowitz, Sharon X. Xie, et al. (+3)
314 [GO] Journal of Clinical Investigation 2020―May―27 COVID-19, microangiopathy, hemostatic activation, and complement Wen-Chao Song, Garret A. FitzGerald
315 [GO] JCI Insight 2020―May―19 Clinical and pathological investigation of severe COVID-19 patients Shaohua Li, Lina Jiang, Xi Li, Fang Lin, Yijin Wang, Boan Li, et al. (+17)
316 [GO] Journal of Clinical Investigation 2020―May―11 Clinical trials for COVID-19 should include sex as a variable Evelyne Bischof, Jeannette Wolfe, Sabra L. Klein
317 [GO] JCI Insight 2020―May―07 Molecular detection of SARS-CoV-2 in formalin-fixed, paraffin-embedded specimens Jun Liu, April M. Babka, Brian J. Kearney, Sheli R. Radoshitzky, Jens H. Kuhn, Xiankun Zeng
318 [GO] Journal of Clinical Investigation 2020―Apr―30 Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists Maximilian F. Konig, Michael A. Powell, Verena Staedtke, Ren-Yuan Bai, David L. Thomas, Nicole M. Fischer, et al. (+12)
319 [GO] JCI Insight 2020―Apr―30 Characteristics and diagnosis rate of 5,630 subjects receiving SARS-CoV-2 nucleic acid tests from Wuhan, China Na Shen, Yaowu Zhu, Xiong Wang, Jing Peng, Weiyong Liu, Feng Wang, et al. (+3)
320 [GO] Journal of Clinical Investigation 2020―Apr―30 Prototype pathogen approach for pandemic preparedness: world on fire Barney S. Graham, Kizzmekia S. Corbett
321 [GO] JCI Insight 2020―Apr―24 Neutrophil extracellular traps in COVID-19 Yu Zuo, Srilakshmi Yalavarthi, Hui Shi, Kelsey Gockman, Melanie Zuo, Jacqueline A. Madison, et al. (+7)
322 [GO] Journal of Clinical Investigation 2020―Apr―24 Panic prescribing has become omnipresent during the COVID-19 pandemic Arthur L. Caplan, Ross Upshur
323 [GO] JCI Insight 2020―Apr―23 The laboratory tests and host immunity of COVID-19 patients with different severity of illness Feng Wang, Hongyan Hou, Ying Luo, Guoxing Tang, Shiji Wu, Min Huang, et al. (+7)
324 [GO] JCI Insight 2020―Apr―17 COVID-19 in older adults: clinical, psychosocial, and public health considerations John P. Mills, Keith S. Kaye, Lona Mody
325 [GO] Journal of Clinical Investigation 2020―Apr―07 Deployment of convalescent plasma for the prevention and treatment of COVID-19 Evan M. Bloch, Shmuel Shoham, Arturo Casadevall, Bruce S. Sachais, Beth Shaz, Jeffrey L. Winters, et al. (+21)
326 [GO] Journal of Clinical Investigation 2020―Apr―06 Kidney diseases in the time of COVID-19: major challenges to patient care Hamid Rabb
327 [GO] Journal of Clinical Investigation 2020―Apr―03 The COVID-19 pandemic and research shutdown: staying safe and productive M. Bishr Omary, Jeetendra R. Eswaraka, S. David Kimball, Prabhas V. Moghe, Reynold A. Panettieri, Jr., Kathleen W. Scotto
328 [GO] Journal of Clinical Investigation 2020―Mar―30 COVID-19 threatens health systems in sub-Saharan Africa: the eye of the crocodile Elijah Paintsil
329 [GO] Journal of Clinical Investigation 2020―Mar―27 Clinical and immunologic features in severe and moderate Coronavirus Disease 2019 Guang Chen, Di Wu, Wei Guo, Yong Cao, Da Huang, Hongwu Wang, et al. (+14)
330 [GO] Journal of Clinical Investigation 2020―Mar―27 SARS-CoV-2: A Storm is Raging Savannah F. Pedersen, Ya-Chi Ho
331 [GO] Journal of Clinical Investigation 2020―Mar―22 Changing the editorial process at JCI and JCI Insight in response to the COVID-19 pandemic Rexford S. Ahima, Sarah Jackson, Arturo Casadevall, Gregg L. Semenza, Gordon Tomaselli, Kathleen L. Collins, et al. (+3)
332 [GO] Journal of Clinical Investigation 2020―Mar―13 The convalescent sera option for containing COVID-19 Arturo Casadevall, Liise-anne Pirofski
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