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Vaccine boosters

The delivery device of SARS-CoV-2 mucosal vaccine matters

Nature Immunology volume 25, pages 1781–1783 (2024)Cite this article

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Mucosal vaccine boosters are expected to enhance protection against SARS-CoV-2 infection. A study now reveals that the delivery device — through either intranasal sprayers or nebulizers — also influences the mucosal immunity and protection efficacy in non-human primates.

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Fig. 1: Mucosal immunogenicity and efficacy of an intranasal or aerosolized adenoviral vector-based bivalent vaccine in non-human primates.

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Authors and Affiliations

  1. Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China

    Fanchong Jian & Yunlong Cao

  2. Changping Laboratory, Beijing, China

    Fanchong Jian & Yunlong Cao

  3. College of Chemistry and Molecular Engineering, Peking University, Beijing, China

    Fanchong Jian

Authors
  1. Fanchong Jian
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  2. Yunlong Cao
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Corresponding author

Correspondence to Yunlong Cao.

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Competing interests

Y.C. is listed as an inventor of provisional patent applications of SARS-CoV-2 monoclonal antibodies. Y.C. is a co-founder of Singlomics Biopharmaceuticals and maintains commercial collaborations with Sinovac Inc. and Moderna Inc. F.J. declares no competing interests.

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Jian, F., Cao, Y. The delivery device of SARS-CoV-2 mucosal vaccine matters. Nat Immunol 25, 1781–1783 (2024). https://doi.org/10.1038/s41590-024-01950-6

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