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Two case reports of skin vasculitis following the COVID-19 immunization

  • Anželika Chomičienė , Kęstutis Černiauskas , Kotryna Linauskienė EMAIL logo , Raimundas Meškauskas and Laura Malinauskienė
Published/Copyright: December 9, 2022
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Open Medicine
From the journal Open Medicine Volume 17 Issue 1

Abstract

The coronavirus 2019 (COVID-19) disease is now responsible for one of the most challenging and concerning pandemics. Since December 2020, the world has had access to COVID-19 prophylaxis; thus, we encounter adverse events from vaccination more often due to the vast vaccination range. We present two case reports of difficult-to-treat skin vasculitis due to COVID-19 vaccination that were successfully treated in a tertiary-level university hospital. When encountering systemic treatment, resistant skin vasculitis plasmapheresis could be a choice of treatment.

Keywords: case report; COVID-19 disease; vaccine; vasculitis; plasmapheresis; mRNA vaccine; adverse events

1 Introduction

The coronavirus 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had terrible health, economic, and social consequences. As vaccines for the novel COVID-19 disease are already authorized in many countries around the world, knowledge about adverse events following immunization (AEFI) is essential for medical practitioners and health authorities in the context of the safety and tolerability of vaccines. An AEFI is defined as any untoward medical occurrence that follows immunization and does not necessarily have a causal relationship with the use of a vaccine [1]. We present two cases of vasculitis after immunization with the Pfizer Comirnaty COVID-19 vaccine.

2 First case

A 65-year-old otherwise healthy woman was consulted at our center in February 2021 because of severe urticaria and angioedema. She reported that hives appeared 12 days post-vaccination with the second dose of the Pfizer Comirnaty COVID-19 vaccine and lasted for 2 weeks. She denied having other symptoms such as fever, fatigue, headache, nausea, muscle or joint pains, a local reaction at the injection site, or swelling in the underarm. Urticarial rash and angioedema episodes of the lips and ears were associated with burning sensation and pruritus. On the initial physical examination, next to typical urticaria on the limbs and trunk, some palpable non-blanching purpuric papules were noticed on the thighs (Figure 1). The rest of the physical examination was unremarkable. The patient did not refer to any relevant past medical history. She did not take any medications and had no allergies to vaccines, drugs, or food in the past. Full blood workup, including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and immunologic tests (C3, C4, antinuclear antibodies (ANA), antineutrophil cytoplasmic antibody (ANCA), and cryoglobulins), was done the following day, and all were normal, except for a moderately elevated white blood cells (11.9 × 109/L) with predominant neutrophils (72.2%), which was attributed to previous treatment with corticosteroids. The Chest X-ray showed no abnormalities. There were several erythrocytes in the urine analysis. A skin biopsy was taken. Histopathologic findings revealed mild mixed perivascular infiltration of lymphocytes and neutrophils in the superficial dermis, a thin interstitial neutrophil infiltrate of the derma, oedema of the vascular endothelium, and vessel wall necrosis, but no signs of IgA vasculitis were found (Figure 1).

Figure 1 Urticarial and palpable non-blanching purpuric rash compatible with mild mixed perivascular infiltration of lymphocytes and neutrophils in the superficial dermis, oedema of blood vessels endothelium, no vessels wall necrosis identified.
Figure 1

Urticarial and palpable non-blanching purpuric rash compatible with mild mixed perivascular infiltration of lymphocytes and neutrophils in the superficial dermis, oedema of blood vessels endothelium, no vessels wall necrosis identified.

The urticarial vasculitis (UV) was diagnosed, and the patient was treated with 32 mg of oral methylprednisolone, 20 mg omeprazole, and 40 mg per day rupatadine. She also received several intravenous injections of dexamethasone. Plasmapheresis is often used in our clinic in cases when other therapies fail. Plasmapheresis was started after 6 days of unsuccessful treatment with medications, and the patient had an overall five procedures. After two procedures of plasmapheresis, the urticaria disappeared and did not reoccur. Therefore, systemic steroids were tapered gradually for 1 month. The patient recovered completely. She was followed up for 1 year.

3 Second case

A 49-year-old woman was consulted by an allergologist and clinical immunologist because of a rash on her extremities. The rash appeared 3 weeks after the first dose of the Pfizer Comirnaty COVID-19 vaccine. The patient felt weakness and pain in the shins. Earlier the patient was consulted by another allergologist, vasculitis was suspected, and treatment with triamcinolone acetonide 40 mg injection started every 3 weeks. The improvement was only temporary, and after 4 months, she was consulted by the rheumatologist and hospitalized at the Center for Rheumatology with suspicion of systemic vasculitis. On physical examination, a palpable non-blanching purpuric rash on all extremities (Figure 2) was evident with some small sores with necrosis on the right shin (Figure 2). No other symptoms (fever, fatigue, or joint pain) were observed. The patient had leukocytosis (up to 12.57 × 10 9/L) with 74.9% neutrophils and normal platelet (242 × 109/L) and eosinophil (0.00 × 109/L) counts. CRP, ESR, urinalysis, creatinine, liver function tests, C3, and C4 were within normal limits. ANA, ANCA, human immunodeficiency virus, hepatitis B virus surface antigen, and hepatitis C virus antibodies were negative. The chest X-ray showed no abnormalities. Abdominal echoscopy showed hepatosteatosis and calcinate in the right kidney. Histopathologic investigation of the skin biopsy revealed small-vessel oedema of the endothelium with perivascular leukocytoclasis, erythrocytes extravasation, and focal IgA deposition in the vessels (Figure 3). IgA vasculitis (Henoch-Schönlein purpura) was diagnosed. The patient was treated with 32 mg of oral methylprednisolone and a plasmapheresis course. The rash disappeared after 4 weeks. Systemic steroids were tapered gradually for 6 weeks. The patient recovered completely and was followed up for 1 year.

Figure 2 A palpable non-blanching purpuric rash on the right thigh and a sore with necrosis signs on the right shin.
Figure 2

A palpable non-blanching purpuric rash on the right thigh and a sore with necrosis signs on the right shin.

Figure 3 Small vessels oedema of endothelium with perivascular leukocytoclasis, erythrocytes extravasation with focal IgA deposition in the vessels.
Figure 3

Small vessels oedema of endothelium with perivascular leukocytoclasis, erythrocytes extravasation with focal IgA deposition in the vessels.

Both of the patients gave written consent for the publication of the case report.

4 Discussion

COVID-19 patients present with many extra-respiratory manifestations in addition to respiratory symptoms and fever [2]. A constituent number of case reports and clinical series have already been published describing a complex spectrum of skin manifestations associated with the SARS-CoV-2 infection [3,4,5]. Skin lesions with features of vasculitis have been reported in COVID-19 cases, ranging from mild or asymptomatic to fulminant disease [6,7,8]. In addition, there are some reports in the recent literature of cutaneous vasculitis secondary to COVID-19 vaccination [9,10,11].

Based on the clinical presentation and histological features, a clinical diagnosis of UV was made in our first patient. UV is a small-vessel vasculitis with predominantly skin involvement manifesting as urticarial lesions. Angioedema is present in less than half of patients. UV is attributed to the deposition of immune complexes on the blood vessel wall [11]. UV is more often idiopathic, but in some cases, it could occur secondary to an underlying infection, connective tissue disorders, malignancy, and medications.

IgA vasculitis, or Henoch-Schönlein purpura, is a rare autoimmune disease that usually presents in the paediatric and teenage population. IgA vasculitis is often linked to viral or bacterial infection, and a particular association with vaccination has also been documented. IgA vasculitis is often associated with influenza vaccination and usually occurs within 21 days after administration of the influenza vaccine and most affected patients (73%) are younger than 17 years old, it is usually a self-limiting illness [12]. We present an atypical case report of Ig A vasculitis in a middle-aged woman with a progression of skin rash over 4 months despite treatment with systemic corticosteroids.

Vasculitides have been reported as AEFI with several types of vaccines, and the literature review showed numerous reports of vasculitides following vaccination described in a limited number of controlled studies [13]. An important criterion guiding the causality assessment of each event is the temporal relationship between the vaccine and the event, which is deemed to be in the range of 1–6 weeks for drug and vaccine-induced vasculitis. In our cases, it was 12 and 21 days. According to the descriptive analyses across three international databases, vasculitides were more frequently reported in association with influenza vaccines than with any other vaccine. The distribution of vasculitis events by gender showed a slight female predominance (54.3%). Vasculitis appears to be less frequently reported in the elderly (in 15.5% of vaccinated persons on average). Among those patients with the recorded outcomes, 44.3% recovered, 1% had a fatal outcome, and 55% had not recovered/not resolved or the outcome was unknown [14,15].

The exact pathogenesis of vaccination-associated vasculitis has yet to be determined, but the SARS-CoV-2 vaccine might result in the activation of autoreactive B/T cells, antibody formation, and immune complex deposition within small vessels, leading to activation of the complement system and recruitment of leukocytes. The responsible particle as an antigen for such reactions is unknown; however, inflammatory response to a vaccine component encoding SARS‐CoV‐2 spike glycoprotein, targeting the endothelium and resulting in small-vessel vasculitis, could be hypothesized [11]. We described two cases of different types of skin vasculitis following COVID-19 immunization, successfully treated with plasmapheresis and systemic corticosteroids.

The safety of future vaccination in patients with a prior diagnosis of vasculitis due to a vaccine is debatable.

Abbreviations

AEFI

adverse events following immunization.

UV

urticarial vasculitis

tel: +37-061114673

  1. Funding information: No external funding source for this study.

  2. Conflict of interest: The authors have no conflict of interest to declare.

  3. Data availability statement: The data that support the findings of these cases are available from the corresponding author upon reasonable request.

References

[1] Council for International Organizations of Medical Sciences (CIOMS). Definition and application of terms for vaccine pharmacovigilance: report of CIOMS/WHO Working Group on Vaccine Pharmacovigilance. Geneva: Council for International Organizations of Medical Sciences (CIOMS); 2012.Search in Google Scholar

[2] Gupta A, Madhavan MV, Seghal K, Nair N, Mahajan S, Sehrawat TS, et al. Extrapulmonary manifestations of COVID-19. Nat Med. 2020;26(7):1017–32.10.1038/s41591-020-0968-3Search in Google Scholar PubMed

[3] Gisondi P, Piaserico S, Bordin C, Alaibac M, Girolomoni G, Naldi L. Cutaneous manifestations of SARS‐CoV‐2 infection: a clinical update. JEADV. 2020;34(11):2499–504.10.1111/jdv.16774Search in Google Scholar PubMed PubMed Central

[4] Bouaziz JD, Duong TA, Jachiet M, Velter C, Lestang P, Cassius C, et al. Vascular skin symptoms in COVID-19: a French observational study. JEADV. 2020;34:e433–531.10.1111/jdv.16544Search in Google Scholar PubMed PubMed Central

[5] Novak N, Peng W, Naegeli MC, Galvan C, Kolm-Djamei I, Brüggen C, et al. SARS‐CoV‐2, COVID‐19, skin and immunology – What do we know so far? Allergy. 2021;76:698–713.10.1111/all.14498Search in Google Scholar PubMed PubMed Central

[6] McGonagle D, Bridgewood C, Ramanan AV, Maeneu JFM, Watad A. COVID-19 vasculitis and novel vasculitis mimics. Lancet Rheumatol. 2021;3:e224–33.10.1016/S2665-9913(20)30420-3Search in Google Scholar PubMed PubMed Central

[7] Gomez MC, Gonzales-Cruz C, Ferrer B, Barbera MJ. Leucocytoclastic vasculitis in a patient with COVID-19 with positive SARS-CoV-2 PCR in skin biopsy. BMJ Case Rep. 2020;13:e238039.10.1136/bcr-2020-238039Search in Google Scholar PubMed PubMed Central

[8] Iraji F, Galenhdari H, Siadat AH, Jazi SB. Cutaneous leukocytoclastic vasculitis secondary to COVID-19 infection: A case report. Clin Case Rep. 2021;9:830–34.10.1002/ccr3.3596Search in Google Scholar PubMed PubMed Central

[9] Dash S, Behera B, Sethy M, Mishra J, Garg S. COVID-19 vaccine-induced urticarial vasculitis. Dermatol Therapy. 2021;34:e15093.10.1111/dth.15093Search in Google Scholar PubMed PubMed Central

[10] Larson V, Seidenberg R, Caplan A, Brinster NK, Meehan SA, Kim RH. Clinical and histopathological spectrum of delayed adverse cutaneous reactions following COVID-19 vaccination. J Cutan Pathol. 2022;49(1):34–41.10.1111/cup.14104Search in Google Scholar PubMed PubMed Central

[11] Fiorillo G, Pancetti S, Cortese A. Leukocytoclastic vasculitis (cutaneous small-vessel vasculitis) after COVID-19 vaccination. J Autoimm. 2022;127:102783.10.1016/j.jaut.2021.102783Search in Google Scholar PubMed PubMed Central

[12] Peroni A, Colato C, Zanoni G, Girolomoni G. Urticarial lesions: If not urticaria, what else? The differential diagnosis of urticaria. Part II. Systemic diseases. J Am Acad Dermatol. 2010;62(4):557–70.10.1016/j.jaad.2009.11.687Search in Google Scholar PubMed

[13] Malek A, Gomez-Villegas SI, Hoz A, Nowbakht C, Arias CA. A 19-year old man with IgA vasculitis after vaccination. Braz J Infect Dis. 2018;22(5):442–4.10.1016/j.bjid.2018.09.004Search in Google Scholar PubMed PubMed Central

[14] Bonetto C, Trotta F, Felicetti P, Alarcón GS, Santuccio C, Bachtiar NS, et al. Vasculitis as an adverse event following immunization – systematic literature review. Vaccine. 2016;34:6641–51.10.1016/j.vaccine.2015.09.026Search in Google Scholar PubMed

[15] Felicetti P, Trotta F, Bonetto C, Santuccio C, Pernus YB, Bergner D, et al. Spontaneous reports of vasculitis as an adverse event following immunization: a descriptive analysis across three international databases. Vaccine. 2016;34:6634–40.10.1016/j.vaccine.2015.09.027Search in Google Scholar PubMed

Received: 2022-05-09
Revised: 2022-11-04
Accepted: 2022-11-04
Published Online: 2022-12-09

© 2022 the author(s), published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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  170. MGST1 alleviates the oxidative stress of trophoblast cells induced by hypoxia/reoxygenation and promotes cell proliferation, migration, and invasion by activating the PI3K/AKT/mTOR pathway
  171. Bifidobacterium lactis Probio-M8 ameliorated the symptoms of type 2 diabetes mellitus mice by changing ileum FXR-CYP7A1
  172. circRNA DENND1B inhibits tumorigenicity of clear cell renal cell carcinoma via miR-122-5p/TIMP2 axis
  173. EphA3 targeted by miR-3666 contributes to melanoma malignancy via activating ERK1/2 and p38 MAPK pathways
  174. Pacemakers and methylprednisolone pulse therapy in immune-related myocarditis concomitant with complete heart block
  175. miRNA-130a-3p targets sphingosine-1-phosphate receptor 1 to activate the microglial and astrocytes and to promote neural injury under the high glucose condition
  176. Review Articles
  177. Current management of cancer pain in Italy: Expert opinion paper
  178. Hearing loss and brain disorders: A review of multiple pathologies
  179. The rationale for using low-molecular weight heparin in the therapy of symptomatic COVID-19 patients
  180. Amyotrophic lateral sclerosis and delayed onset muscle soreness in light of the impaired blink and stretch reflexes – watch out for Piezo2
  181. Interleukin-35 in autoimmune dermatoses: Current concepts
  182. Recent discoveries in microbiota dysbiosis, cholangiocytic factors, and models for studying the pathogenesis of primary sclerosing cholangitis
  183. Advantages of ketamine in pediatric anesthesia
  184. Congenital adrenal hyperplasia. Role of dentist in early diagnosis
  185. Migraine management: Non-pharmacological points for patients and health care professionals
  186. Atherogenic index of plasma and coronary artery disease: A systematic review
  187. Physiological and modulatory role of thioredoxins in the cellular function
  188. Case Reports
  189. Intrauterine Bakri balloon tamponade plus cervical cerclage for the prevention and treatment of postpartum haemorrhage in late pregnancy complicated with acute aortic dissection: Case series
  190. A case of successful pembrolizumab monotherapy in a patient with advanced lung adenocarcinoma: Use of multiple biomarkers in combination for clinical practice
  191. Unusual neurological manifestations of bilateral medial medullary infarction: A case report
  192. Atypical symptoms of malignant hyperthermia: A rare causative mutation in the RYR1 gene
  193. A case report of dermatomyositis with the missed diagnosis of non-small cell lung cancer and concurrence of pulmonary tuberculosis
  194. A rare case of endometrial polyp complicated with uterine inversion: A case report and clinical management
  195. Spontaneous rupturing of splenic artery aneurysm: Another reason for fatal syncope and shock (Case report and literature review)
  196. Fungal infection mimicking COVID-19 infection – A case report
  197. Concurrent aspergillosis and cystic pulmonary metastases in a patient with tongue squamous cell carcinoma
  198. Paraganglioma-induced inverted takotsubo-like cardiomyopathy leading to cardiogenic shock successfully treated with extracorporeal membrane oxygenation
  199. Lineage switch from lymphoma to myeloid neoplasms: First case series from a single institution
  200. Trismus during tracheal extubation as a complication of general anaesthesia – A case report
  201. Simultaneous treatment of a pubovesical fistula and lymph node metastasis secondary to multimodal treatment for prostate cancer: Case report and review of the literature
  202. Two case reports of skin vasculitis following the COVID-19 immunization
  203. Ureteroiliac fistula after oncological surgery: Case report and review of the literature
  204. Synchronous triple primary malignant tumours in the bladder, prostate, and lung harbouring TP53 and MEK1 mutations accompanied with severe cardiovascular diseases: A case report
  205. Huge mucinous cystic neoplasms with adhesion to the left colon: A case report and literature review
  206. Commentary
  207. Commentary on “Clinicopathological features of programmed cell death-ligand 1 expression in patients with oral squamous cell carcinoma”
  208. Rapid Communication
  209. COVID-19 fear, post-traumatic stress, growth, and the role of resilience
  210. Erratum
  211. Erratum to “Tollip promotes hepatocellular carcinoma progression via PI3K/AKT pathway”
  212. Erratum to “Effect of femoral head necrosis cystic area on femoral head collapse and stress distribution in femoral head: A clinical and finite element study”
  213. Erratum to “lncRNA NORAD promotes lung cancer progression by competitively binding to miR-28-3p with E2F2”
  214. Retraction
  215. Expression and role of ABIN1 in sepsis: In vitro and in vivo studies
  216. Retraction to “miR-519d downregulates LEP expression to inhibit preeclampsia development”
  217. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part II
  218. Usefulness of close surveillance for rectal cancer patients after neoadjuvant chemoradiotherapy
DOI:  doi.org/10.1515/med-2022-0608
Keywords for this article
case report; COVID-19 disease; vaccine; vasculitis; plasmapheresis; mRNA vaccine; adverse events
Creative Commons
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  190. A case of successful pembrolizumab monotherapy in a patient with advanced lung adenocarcinoma: Use of multiple biomarkers in combination for clinical practice
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  192. Atypical symptoms of malignant hyperthermia: A rare causative mutation in the RYR1 gene
  193. A case report of dermatomyositis with the missed diagnosis of non-small cell lung cancer and concurrence of pulmonary tuberculosis
  194. A rare case of endometrial polyp complicated with uterine inversion: A case report and clinical management
  195. Spontaneous rupturing of splenic artery aneurysm: Another reason for fatal syncope and shock (Case report and literature review)
  196. Fungal infection mimicking COVID-19 infection – A case report
  197. Concurrent aspergillosis and cystic pulmonary metastases in a patient with tongue squamous cell carcinoma
  198. Paraganglioma-induced inverted takotsubo-like cardiomyopathy leading to cardiogenic shock successfully treated with extracorporeal membrane oxygenation
  199. Lineage switch from lymphoma to myeloid neoplasms: First case series from a single institution
  200. Trismus during tracheal extubation as a complication of general anaesthesia – A case report
  201. Simultaneous treatment of a pubovesical fistula and lymph node metastasis secondary to multimodal treatment for prostate cancer: Case report and review of the literature
  202. Two case reports of skin vasculitis following the COVID-19 immunization
  203. Ureteroiliac fistula after oncological surgery: Case report and review of the literature
  204. Synchronous triple primary malignant tumours in the bladder, prostate, and lung harbouring TP53 and MEK1 mutations accompanied with severe cardiovascular diseases: A case report
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  206. Commentary
  207. Commentary on “Clinicopathological features of programmed cell death-ligand 1 expression in patients with oral squamous cell carcinoma”
  208. Rapid Communication
  209. COVID-19 fear, post-traumatic stress, growth, and the role of resilience
  210. Erratum
  211. Erratum to “Tollip promotes hepatocellular carcinoma progression via PI3K/AKT pathway”
  212. Erratum to “Effect of femoral head necrosis cystic area on femoral head collapse and stress distribution in femoral head: A clinical and finite element study”
  213. Erratum to “lncRNA NORAD promotes lung cancer progression by competitively binding to miR-28-3p with E2F2”
  214. Retraction
  215. Expression and role of ABIN1 in sepsis: In vitro and in vivo studies
  216. Retraction to “miR-519d downregulates LEP expression to inhibit preeclampsia development”
  217. Special Issue Computational Intelligence Methodologies Meets Recurrent Cancers - Part II
  218. Usefulness of close surveillance for rectal cancer patients after neoadjuvant chemoradiotherapy
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