Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Matters Arising
  • Published:

Risk of POTS after vaccine versus COVID-19 confounded

Nature Cardiovascular Research volume 2, pages 871–872 (2023)Cite this article

Subjects

Matters Arising to this article was published on 11 September 2023

The Original Article was published on 12 December 2022

Access through your institution
Buy or subscribe

arising from A.C. Kwan et al. Nature Cardiovascular Research https://doi.org/10.1038/s44161-022-00177-8 (2022)

Postural orthostatic tachycardia syndrome (POTS) may be a sequela of coronavirus disease 2019 (COVID-19). Kwan et al. reported that the risk of POTS was 5.35 times higher after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection compared to after COVID-19 vaccination. However, the risk of POTS was 4.69 times higher before SARS-CoV-2 infection compared to before COVID-19 vaccination. Therefore, the SARS-CoV-2-infected and COVID-19-vaccinated populations were not comparable at baseline, and the finding that POTS-associated diagnoses after SARS-CoV-2 infection were much higher than after COVID-19 vaccination was hopelessly confounded.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Data availability

All data used in this Matters Arising are available in ref. 1.

References

  1. Kwan, A. C. et al. Apparent risks of postural orthostatic tachycardia syndrome diagnoses after COVID-19 vaccination and SARS-CoV-2 infection. Nat. Cardiovasc. Res. 1, 1187–1194 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada

    Ari R. Joffe

Authors
  1. Ari R. Joffe
    View author publications

    You can also search for this author inPubMed Google Scholar

Contributions

The author (A.R.J.) made all contributions to the conception or design of the work; the acquisition, analysis and interpretation of data; drafted the work; approved the submitted version; and agreed both to be personally accountable for the author’s own contributions and to ensure that questions related to the accuracy or integrity of any part of the work are appropriately investigated, resolved and the resolution documented in the literature.

Corresponding author

Correspondence to Ari R. Joffe.

Ethics declarations

Competing interests

The author declares no competing interests.

Peer review

Peer review information

Nature Cardiovascular Research thanks Jennifer Nicholas for her contribution to the peer review of this work.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Joffe, A.R. Risk of POTS after vaccine versus COVID-19 confounded. Nat Cardiovasc Res 2, 871–872 (2023). https://doi.org/10.1038/s44161-023-00329-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s44161-023-00329-4

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing