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Antifungal prophylaxis of COVID-19 associated pulmonary aspergillosis in ventilated patients: one solution does not fit all

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Data availability statement

The full dataset is available upon request by the corresponding author.

References

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Acknowledgements

POSACOVID Study Team Members: Cristina Marelli (Clinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino, Genoa, Italy), Alessio Signori (Section of Biostatistics, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy), Silvia Dettori (Clinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino, Genoa, Italy), Greta Cattardico (Clinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino, Genoa, Italy – University of Genoa, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy), Jonas Frost (Medical University of Graz, Department of Internal Medicine, Division of Infectious Diseases, Excellence Centre for Medical Mycology (ECMM), Graz, Austria) and Florian Reizine (Medical Intensive Care Unit, Rennes University Hospital, Rennes, France).

Funding

This work was funded by Merck Sharp and Dohme Corp., IIS 60879, Juergen Prattes. The funder was not involved in the study design, the conduct of the study, data analysis, or manuscript preparation.

Author information

Author notes

  1. Juergen Prattes and Daniele R. Giacobbe have contributed equally to this study as first authors.

  2. Matteo Bassetti, Jean-Pierre Gangneux, and Martin Hoenigl have contributed equally to this study as last authors.

Authors and Affiliations

  1. Department of Internal Medicine, Division of Infectious Diseases, Excellence Centre for Medical Mycology (ECMM), Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria

    Juergen Prattes & Martin Hoenigl

  2. BioTechMed Graz, Graz, Austria

    Juergen Prattes & Martin Hoenigl

  3. Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy

    Daniele R. Giacobbe & Matteo Bassetti

  4. Clinica Malattie Infettive, IRCCS Ospedale Policlinico San Martino, Genoa, Italy

    Daniele R. Giacobbe & Matteo Bassetti

  5. EHESP, Irset (Institut de Recherche en Santé, Environnement Et Travail)-UMR_S 1085, CHU Rennes, Inserm, Univ Rennes, 35000, Rennes, France

    Jean-Pierre Gangneux

  6. Laboratoire de Parasitologie-Mycologie, Centre National de Référence Pour Les Aspergilloses Chroniques (CNRMA-LA AspC), ECMM Excellence Center for Medical Mycology, Centre Hospitalier Universitaire de Rennes, Rennes, France

    Jean-Pierre Gangneux

Authors
  1. Juergen Prattes
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  2. Daniele R. Giacobbe
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  3. Matteo Bassetti
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  4. Jean-Pierre Gangneux
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  5. Martin Hoenigl
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Consortia

on behalf of POSACOVID Study Group

  • Cristina Marelli
  • , Alessio Signori
  • , Silvia Dettori
  • , Greta Cattardico
  • , Jonas Frost
  •  & Florian Reizine

Corresponding author

Correspondence to Juergen Prattes.

Ethics declarations

Conflicts of interest

JP has received investigator-initiated grants from Pfizer, speaker fees from Pfizer, Gilead, Swedish Orphan Biovitrum and Associates of Cape Code and is a stoke holder of AbbVie Inc. and Novo Nordisk—all outside of the submitted work. MB has received funding for scientific advisory boards, travel, and speaker honoraria from Angelini, Astellas, BioMérieux, Cidara, Gilead, Menarini, MSD, Pfizer, Shionogi, Tetraphase and Nabriva—all outside of the submitted work. DRG reports investigator-initiated grants from Pfizer, Shionogi, BioMérieux, and Gilead Italia, and speaker/advisor fees from Menarini, Pfizer, and Tillotts Pharma—all outside of the submitted work. MH received research funding from Gilead, Astellas, MSD, IMMY, Mundipharma, Scynexis, Shionogi, F2G, and Pfizer—all outside of the submitted work. JPG received personal fundings for scientific advisory boards and speaker honoraria from Gilead, Mundipharma, Shionogi, and Pfizer—all outside of the submitted work.

Ethical approval

The main study protocol was approved by the local ethic committee at the Medical University of Graz, Austria (32-296 ex 19/20). IRCCS Ospedale Policlinico San Martino, Italy and University Hospital of Rennes, France provided data for the groups not receiving prophylaxis. Both centers obtained ethic committee approval by their local ethic committees [163/2020 with an amendment approved at May 5th 2022 (Genoa) and approval number 20.56 (Rennes)].

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The details of the authors involved in the POSACOVID Study Group are given in the acknowledgements.

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Prattes, J., Giacobbe, D.R., Bassetti, M. et al. Antifungal prophylaxis of COVID-19 associated pulmonary aspergillosis in ventilated patients: one solution does not fit all. Intensive Care Med 50, 1375–1377 (2024). https://doi.org/10.1007/s00134-024-07542-0

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