The Ways of the Virus: Interactions of Platelets and Red Blood Cells with SARS-CoV-2, and Their Potential Pathophysiological Significance in COVID-19
Abstract
:1. Introduction
2. Two-Way Interactions of SARS-CoV-2 with RBCs and Their Precursors
3. Interaction of SARS-CoV-2 with Platelets and Its Significance for the Virus
4. Platelets and Endothelium: Ways of Interaction
5. How SARS-CoV-2 Affects Platelets
6. Platelet Subpopulations and Mitochondria in COVID-19
7. Evolution of Coronavirus and Its Hematological Interactions
8. Endothelium, Blood Coagulation, Neutrophils and SARS-CoV-2
- (1)
- The Spike protein activates platelets and neutrophils directly, and the virus also damages the endothelium leading to blood clotting.
- (2)
- Neutrophil extracellular traps activate platelets and blood clotting.
- (3)
- Platelets activate neutrophils in positive feedback and accelerate or even activate [136] blood clotting through their procoagulant activity.
- (4)
- Blood clotting acts as a nexus in the network, as it is activated or accelerated by all three cell types. It further activates platelets in positive feedback. It also acts as the final executor in the system, as this activation of the coagulation cascade ultimately appears to be the immediate cause of increased thrombotic risks and organ failure in COVID-19.
9. Problems and Their Status
10. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Problem | Possibilities | Current Status |
---|---|---|
Presence of SARS-CoV-2 in platelets | 1. Usually present 2. Present in a significant proportion of patients 3. Present in a subgroup of patients 4. Does not enter platelets | Likely present in a significant proportion of patients |
Putative receptors and other molecules involved in platelet binding, entry, and possible transmission of virus by platelets. | ACE2, TMPRSS2, CD147, NRP-1, CD26, AGTR2, Band3, KREMEN1, ASGR1, ANP, TMEM30A, CLEC4G, LDLRAD3, GPIIb-IIIa | Not clear |
Ability to replicate in platelets | 1. Can 2. Cannot | Not likely |
The ability to escape from platelets, or to infect through the absorption of platelets by other cells along with the virus | 1. Can 2. Cannot | Not clear |
The significance of the presence of virus in platelets for the virus | 1. The platelet protects the virus from the immune system 2. The platelet facilitates the transport of the virus. 3. The platelet destroys viruses or contributes to its damage by the immune system. | Not clear |
Pathophysiological significance of the presence of the virus in platelets for hemostasis and the body as a whole | 1. Affects important functional changes in platelets 2. Does not affect, or the effect is not clinically significant | Not clear |
Diagnostic significance of the presence of the virus in platelets | 1. It allows for a prediction of the course of the disease and an adjustment in therapy. 2. It has no prognostic role. | Most studies point to a link between the presence of the virus in platelets and more severe forms of the disease. There is no evidence of successful therapy correction. |
Platelet functional status in COVID-19 | 1. Preactivated/at rest 2. Present/absent procoagulant subpopulation 3. Functional responses improved/deteriorated | 1. Pre-activated 2. The procoagulant subpopulation is present 3. The functional status of platelets is not clear |
Mechanism of platelet activation in COVID-19, mechanism of procoagulant platelet formation | 1. Directly by virus (ACE2 candidates, TMEM-16F) 2. Secondarily, through blood coagulation 3. Secondarily, through the immune system (immunomodulins, alarmins) | Not clear |
Pathophysiological significance of platelet functional changes | 1. Contributes to thrombosis in COVID-19. 2. Contributes to the spread of the virus or other aspects of the disease. 3. There is no pathophysiological significance. | Pathophysiological significance is more likely to exist, but the mechanisms need to be clarified. |
Diagnostic significance of platelet functional changes | 1. Platelet function can be a prognostic biomarker. 2. There is no direct connection. | There are contradictions. ECMO appears to be an important independent factor in the alteration of function. |
Interaction of the virus with RBCs | 1. Interacts with mature RBCs 2. Does not interact | There is no data on such interactions |
Interaction of the virus with erythroid precursors | 1. Interacts 2. Interacts and influences 3. Does not interact | Rather, it interacts, presumably through ACE2. Stimulates reproduction. |
Pathophysiological and diagnostic significance of the effect on erythrocytes | 1. Appearance of immature forms of erythrocytes. 2. Anisocytosis 3. Filtration defects | Pathophysiologically significant, there are associations of erythrocyte status with disease severity and prognosis. |
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Panteleev, M.A.; Sveshnikova, A.N.; Shakhidzhanov, S.S.; Zamaraev, A.V.; Ataullakhanov, F.I.; Rumyantsev, A.G. The Ways of the Virus: Interactions of Platelets and Red Blood Cells with SARS-CoV-2, and Their Potential Pathophysiological Significance in COVID-19. Int. J. Mol. Sci. 2023, 24, 17291. https://doi.org/10.3390/ijms242417291
Panteleev MA, Sveshnikova AN, Shakhidzhanov SS, Zamaraev AV, Ataullakhanov FI, Rumyantsev AG. The Ways of the Virus: Interactions of Platelets and Red Blood Cells with SARS-CoV-2, and Their Potential Pathophysiological Significance in COVID-19. International Journal of Molecular Sciences. 2023; 24(24):17291. https://doi.org/10.3390/ijms242417291
Chicago/Turabian StylePanteleev, Mikhail A., Anastasia N. Sveshnikova, Soslan S. Shakhidzhanov, Alexey V. Zamaraev, Fazoil I. Ataullakhanov, and Aleksandr G. Rumyantsev. 2023. "The Ways of the Virus: Interactions of Platelets and Red Blood Cells with SARS-CoV-2, and Their Potential Pathophysiological Significance in COVID-19" International Journal of Molecular Sciences 24, no. 24: 17291. https://doi.org/10.3390/ijms242417291