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A critical assessment of corticosteroid trials for hospitalised patients with SARS-CoV-2 disease

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References

  1. Horby P, Lim WS, Emberson JR, RECOVERY Collaborative Group et al (2021) Dexamethasone in hospitalized patients with Covid-19. N Engl J Med 384:693–704

    Article  CAS  PubMed  Google Scholar 

  2. WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group (2020) Association between administration of systemic corticosteroids and mortality among critically ill patients with COVID-19: a meta-analysis. JAMA 324:1330–1341

    Article  Google Scholar 

  3. Carlet J, Payen D, Opal SM (2020) Steroids for sepsis and ARDS: this eternal controversy remains with COVID-19. Lancet 396:e61–e62

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Kwon KE, Jung SY, Baek MS, Kim WY (2022). Corticosteroids in H1N1, non-viral, and COVID-19 ARDS. Intensive Care Med 48:1809–1811

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Wagner C, Griesel M, Mikolajewska A et al (2022) Systemic corticosteroids for the treatment of COVID-19: equity-related analyses and update on evidence. Cochrane Database Syst Rev 11(11):CD014963. https://doi.org/10.1002/14651858.CD014963.pub2

    Article  PubMed  Google Scholar 

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Acknowledgements

Additional members of the “Steroids for Covid Research Group”: Michael A Matthay, Cardiovascular Research Institute, University of California, San Francisco, California; Benoît Misset, Rouen University Hospital Charles Nicolle, Rouen, France; Guillaume Monneret, Hospices Civils de Lyon, Lyon, France; Greet Van den Berghe, Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Louvain, Belgium. We would like to thank Professor Jean Marc Cavaillon, Institut Pasteur, Paris, France, for his useful insights.

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Correspondence to Jean Carlet.

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Carlet, J., Payen, D., Singer, M. et al. A critical assessment of corticosteroid trials for hospitalised patients with SARS-CoV-2 disease. Intensive Care Med 51, 972–974 (2025). https://doi.org/10.1007/s00134-025-07878-1

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  • DOI: https://doi.org/10.1007/s00134-025-07878-1